Serum lactate dehydrogenase is a predictive biomarker in patients with oropharyngeal cancer undergoing radiotherapy: Retrospective study on predictive factors
| العنوان: | Serum lactate dehydrogenase is a predictive biomarker in patients with oropharyngeal cancer undergoing radiotherapy: Retrospective study on predictive factors |
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| المؤلفون: | Y. Oguma, Hisato Kawakami, Hiroshi Doi, Yutaro Wada, Makoto Hosono, Saori Tatsuno, Kiyoshi Nakamatsu, Kazuki Ishikawa, Takuya Uehara, Masahiro Inada, Yasumasa Nishimura |
| المصدر: | Head & Neck |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | serum lactate dehydrogenase, Male, medicine.medical_specialty, Multivariate analysis, oropharyngeal cancer, medicine.medical_treatment, head and neck squamous cell carcinoma, Gastroenterology, Internal medicine, medicine, Humans, Stage (cooking), human papillomavirus, Lactate Dehydrogenases, radiotherapy, Neoplasm Staging, Retrospective Studies, Univariate analysis, Squamous Cell Carcinoma of Head and Neck, business.industry, Papillomavirus Infections, Albumin, Cancer, Retrospective cohort study, Original Articles, Prognosis, medicine.disease, Head and neck squamous-cell carcinoma, Radiation therapy, Oropharyngeal Neoplasms, Otorhinolaryngology, Head and Neck Neoplasms, Original Article, business, Biomarkers |
| الوصف: | Background The present study aimed to evaluate the prognostic factors in human papillomavirus (HPV)‐positive and HPV‐negative oropharyngeal cancer (OPC) treated with definitive radiotherapy. Methods We retrospectively evaluated 101 patients with OPC who underwent definitive radiotherapy between 2008 and 2018. Results The median follow‐up period of the surviving patients was 68 months (range, 8–164 months). The 5‐year overall survival rate was 69.8%. Univariate analyses revealed that poor survival was associated with male sex, smoking ≥30 pack‐years, Eastern Cooperative Oncology Group performance status ≥1, tumor‐node‐metastasis (TNM) stage III‐IV (8th edition), HPV‐negativity, serum lactate dehydrogenase (LDH) ≥202, C‐reactive protein/albumin ratio ≥0.15, and lymphocyte‐to‐monocyte ratio |
| تدمد: | 1097-0347 1043-3074 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7fb514e6dc53b7789a07eff2453fd2Test https://doi.org/10.1002/hed.26814Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4e7fb514e6dc53b7789a07eff2453fd2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970347 10433074 |
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