Advancing intraoperative magnetic tracing using 3D freehand magnetic particle imaging
| العنوان: | Advancing intraoperative magnetic tracing using 3D freehand magnetic particle imaging |
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| المؤلفون: | Lennert Molenaar, Lejla Alic, Mick M. Welling, Melissa Mathilde van de Loosdrecht, Samaneh Azargoshasb, Danny M. van Willigen, Tessa Buckle, Fijs W. B. van Leeuwen, Alexander Winter, Matthias N. van Oosterom, Giuseppe Rosiello |
| المساهمون: | TechMed Centre, Magnetic Detection and Imaging |
| المصدر: | International Journal of Computer Assisted Radiology and Surgery International journal of computer assisted radiology and surgery, 17(1), 211-218. Springer International Journal of Computer Assisted Radiology and Surgery, 17(1), 211-218. SPRINGER HEIDELBERG |
| بيانات النشر: | Springer International Publishing, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Indocyanine Green, Fluorescence-lifetime imaging microscopy, Magnetometer, Computer science, Swine, Sentinel lymph node, Biomedical Engineering, Health Informatics, Augmented reality, Imaging phantom, 030218 nuclear medicine & medical imaging, law.invention, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Magnetic particle imaging, Imaging, Three-Dimensional, law, Animals, Humans, Radiology, Nuclear Medicine and imaging, Surgical navigation, Magnetic particle-guided surgery, Modality (human–computer interaction), Sentinel Lymph Node Biopsy, Optical Imaging, General Medicine, Penile cancer, Computer Graphics and Computer-Aided Design, Computer Science Applications, chemistry, Surgery, Computer-Assisted, 030220 oncology & carcinogenesis, Magnetic nanoparticles, Fluorescence-guided surgery, Surgery, Original Article, Computer Vision and Pattern Recognition, Indocyanine green, Biomedical engineering |
| الوصف: | Purpose Sentinel lymph node biopsy is a routine procedure for nodal staging in penile cancer. Most commonly, this procedure is guided by radioactive tracers, providing various forms of preoperative and intraoperative guidance. This is further extended with fluorescence imaging using hybrid radioactive–fluorescence tracers. Alternatively, a magnetic-based approach has become available using superparamagnetic iron-oxide nanoparticles (SPIONs). This study investigates a novel freehand magnetic particle imaging and navigation modality (fhMPI) for intraoperative localization, along with a hybrid approach, combining magnetic and fluorescence guidance. Materials and methods The fhMPI set-up was built with a surgical navigation device, optical tracking system and magnetometer probe. A dedicated reconstruction software based on a look-up-table method was used to reconstruct a superficial 3D volume of the SPION distribution in tissue. For fluorescence guidance, indocyanine green (ICG) was added to the SPIONs. The fhMPI modality was characterized in phantoms, ex vivo human skin and in vivo porcine surgery. Results Phantom and human skin explants illustrated that the current fhMPI modality had a sensitivity of 2.2 × 10–2 mg/mL SPIONs, a resolving power of at least 7 mm and a depth penetration up to 1.5 cm. Evaluation during porcine surgery showed that fhMPI allowed for an augmented reality image overlay of the tracer distribution in tissue, as well as 3D virtual navigation. Besides, using the hybrid approach, fluorescence imaging provided a visual confirmation of localized nodes. Conclusion fhMPI is feasible in vivo, providing 3D imaging and navigation for magnetic nanoparticles in the operating room, expanding the guidance possibilities during magnetic sentinel lymph node procedures. Furthermore, the integration of ICG provides the ability to visually refine and confirm correct localization. Further clinical evaluation should verify these findings in human patients as well. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1861-6429 1861-6410 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de984c5d69ef094429b2883441c965eTest http://europepmc.org/articles/PMC8738628Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4de984c5d69ef094429b2883441c965e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18616429 18616410 |
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