Incidence and Patterns of Second Primary Malignancies Following Oral Cavity Cancers in a Prevalent Area of Betel-nut Chewing: A Population-based Cohort of 26 166 Patients in Taiwan
| العنوان: | Incidence and Patterns of Second Primary Malignancies Following Oral Cavity Cancers in a Prevalent Area of Betel-nut Chewing: A Population-based Cohort of 26 166 Patients in Taiwan |
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| المؤلفون: | Feng Che Kuan, Kuan Der Lee, Min Chi Chen, Shih How Huang, Cih-En Huang, Miao Fen Chen, Ping Tsung Chen |
| المصدر: | Japanese Journal of Clinical Oncology. 41:1336-1343 |
| بيانات النشر: | Oxford University Press (OUP), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Male, Risk, Cancer Research, medicine.medical_specialty, Population, Taiwan, Age Distribution, Asian People, Internal medicine, Humans, Medicine, Radiology, Nuclear Medicine and imaging, education, Survival rate, Areca, Aged, Proportional Hazards Models, education.field_of_study, biology, business.industry, Proportional hazards model, Incidence, Incidence (epidemiology), Cancer, Neoplasms, Second Primary, General Medicine, Middle Aged, Betel, biology.organism_classification, medicine.disease, Surgery, Cancer registry, Survival Rate, Standardized mortality ratio, Oncology, Female, Mouth Neoplasms, business |
| الوصف: | Objective: The incidence of oral cavity cancers is increasing rapidly in South-East Asia, which may be attributable to tobacco smoking, alcohol and betel-nut chewing. However, the actual incidence and risk of second primary malignancies after oral cavity cancers have not been well established in this region. A population-based study was therefore conducted. Methods: Standardized incidence ratios and cumulative incidences were calculated for second primary cancers using the Taiwan Cancer Registry database for the period 1979–2003, which included 26 166 cases having an initial diagnosis of oral cavity cancers. Results: A 3.11-fold increase in risk for second cancer at all sites was observed after oral cavity cancers compared with the general population (standardized incidence ratio ¼ 3.11, 95% confidence interval: 2.97–3.25). Of nine sites with excess risks of developing a second cancer, the frequency was highest in the oral/pharynx (60%), followed by lung (7.2%) and esophagus (5.5%). Second esophageal and lung cancers had a greater impact on survival compared with other types of second cancer. Notably, the risk excess was more prominent for patients with a follow-up interval of 1 year and a first primary cancer diagnosed at age of 40. These patients may justify closer surveillance. Conclusions: This is the largest population-based study with a homogeneous patient population focusing on oral cavity cancers within a high-incidence area. We found that oral cavity cancers are associated with an increased risk of nine second malignancies, which had a negative impact on survival. |
| تدمد: | 1465-3621 0368-2811 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dda953b0476e31bbedb7e1b46f3fd1aTest https://doi.org/10.1093/jjco/hyr152Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4dda953b0476e31bbedb7e1b46f3fd1a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14653621 03682811 |
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