Worsening Postural Tachycardia Syndrome is Associated with Increased Glucose Dependent Insulinotropic Polypeptide Secretion
| العنوان: | Worsening Postural Tachycardia Syndrome is Associated with Increased Glucose Dependent Insulinotropic Polypeptide Secretion |
|---|---|
| المؤلفون: | Nicholas C. Breier, Sachin Y. Paranjape, Shea Scudder, Shahram E. Mehr, Andre’ Diedrich, Charles R. Flynn, Luis E. Okamoto, Bolette Hartmann, Lærke Smidt Gasbjerg, Cyndya A. Shibao |
| المصدر: | Hypertension Breier, N C, Paranjape, S Y, Scudder, S, Mehr, S E, Diedrich, A, Flynn, C R, Okamoto, L E, Hartmann, B, Gasbjerg, L S & Shibao, C A 2022, ' Worsening Postural Tachycardia Syndrome Is Associated With Increased Glucose-Dependent Insulinotropic Polypeptide Secretion ', Hypertension, vol. 79, no. 5, pp. e89-e99 . https://doi.org/10.1161/HYPERTENSIONAHA.121.17852Test |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, carbohydrates, blood pressure, Blood Pressure, tachycardia, Article, Gastrointestinal Hormones, Postural Orthostatic Tachycardia Syndrome, Glucose, Heart Rate, Case-Control Studies, Tachycardia, Internal Medicine, heart rate, Humans, Female, Prospective Studies, glucose, incretins, Acetaminophen |
| الوصف: | Background: Postural tachycardia syndrome (POTS) is characterized by excessive upright tachycardia and disabling presyncopal symptoms, which are exacerbated after consuming a high-carbohydrate meal; it is unknown, however, what is the precise underlying mechanism. We seek to investigate the effect of glucose intake on orthostatic hemodynamic changes and gastrointestinal hormone secretion in POTS. Methods: Prospective, case-control study, 12 women with POTS who reported a postprandial worsening of their POTS symptoms and 13 age-matched female controls received 75-g oral glucose and 20 mg/kg acetaminophen to assess nutrient absorption. Hemodynamic, gastrointestinal hormone and acetaminophen levels were measured for up to 120 minutes postingestion while supine and standing. Results: Patients with POTS had significant orthostatic tachycardia, 48.7±11.2 versus 23.3±8.1 bpm, P =0.012 and elevated upright norepinephrine levels, 835.2±368.4 versus 356.9±156.7 pg/mL, P =0.004. After oral glucose, upright heart rate significantly increased in POTS, 21.2±11.9% versus 6.0±19.9%, P =0.033 with a concomitant decline in upright stroke volume, −10.3±11.90% versus 3.3±13.7%, P =0.027; total peripheral resistance, blood pressure and cardiac output remained unaltered. Acetaminophen rate of appearance was similar between groups ( P =0.707), indicating comparable nutrient absorption rates. POTS had increased plasma levels of C-peptide ( P =0.001), GIP (glucose-dependent insulinotropic polypeptide; P =0.001), peptide YY ( P =0.016), and pancreatic polypeptide ( P =0.04) following glucose consumption, but only GIP had a time-dependent association with the worsening upright tachycardia and stroke volume fall. Conclusions: The glucose-induced worsening orthostatic tachycardia in POTS was associated with a decline in SV; these changes occurred while GIP, a splanchnic vasodilator, was maximally elevated. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9a684fdde1b412c4f9a3c41a40eb0dTest https://europepmc.org/articles/PMC9010371Test/ |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4d9a684fdde1b412c4f9a3c41a40eb0d |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |