The endothelin 1 and endothelin receptor A gene polymorphisms increase the risk of developing papillary thyroid cancer
| العنوان: | The endothelin 1 and endothelin receptor A gene polymorphisms increase the risk of developing papillary thyroid cancer |
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| المؤلفون: | Pervin Vural, Semra Doğru-Abbasoğlu, A. Fatih Aydın, Esra Çil |
| المصدر: | Molecular Biology Reports. 46:199-205 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Genotype, endocrine system diseases, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Papillary thyroid cancer, 03 medical and health sciences, 0302 clinical medicine, Gene Frequency, Risk Factors, Internal medicine, Genetics, medicine, Humans, SNP, Genetic Predisposition to Disease, Thyroid Neoplasms, Allele, Molecular Biology, Alleles, Aged, Endothelin-1, Receptors, Endothelin, business.industry, Endothelins, General Medicine, Middle Aged, Receptor, Endothelin A, medicine.disease, Endothelin 1, 030104 developmental biology, Thyroid Cancer, Papillary, Tumor progression, 030220 oncology & carcinogenesis, Population study, Female, business |
| الوصف: | The endothelin (EDN) axis (EDN1 and EDN1 receptor A, EDNRA) is involved in cellular growth, differentiation, invasiveness, and tumor progression in several cancers. We wanted to examine the possible impact of single nucleotide polymorphisms (SNPs) of EDN1 and EDNRA genes on papillary thyroid cancer (PTC) development and general characteristics of PTC. Study population consist of 113 PTC patients and 185 controls. EDN1 (G5665T, T-1370G) and EDNRA (C TT70G, G-231A) SNPs were investigated by real-time PCR. The GG genotype of EDNRA + 70 SNP was associated with threefold increased PTC risk (p = 0.01), and the combined CG + GG genotype was 2.48 fold higher among PTC patients compared to controls. The variant EDNRA - 231 allele was overrepresented in PTC patients according to controls (p = 0.05). The combined GT + TT genotype of EDN1 5665 SNP was related with late (age after 40 years) PTC onset (p = 0.04), and was more prominent among male patients with PTC according to females (p = 0.03). No significant associations between PTC and - 1370 SNP were found. There were no relationships between laboratory parameters and investigated polymorphisms. The EDNRA + 70 SNP was associated with PTC development. The EDN1 5665 SNP was linked with increased risk for late PTC onset and was more prominent among male patients with PTC. |
| تدمد: | 1573-4978 0301-4851 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d96a9d5763b7af2f7b318639f740e0fTest https://doi.org/10.1007/s11033-018-4461-8Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4d96a9d5763b7af2f7b318639f740e0f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15734978 03014851 |
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