The Long-Term Effects of Type 1 Diabetes Treatment and Complications on Health-Related Quality of Life
| العنوان: | The Long-Term Effects of Type 1 Diabetes Treatment and Complications on Health-Related Quality of Life |
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| المؤلفون: | Rose Gubitosi-Klug, Alan M. Jacobson, Patricia A. Cleary, Barbara H. Braffett, Mary E. Larkin |
| المصدر: | Diabetes Care |
| بيانات النشر: | American Diabetes Association, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Blood Pressure, Body Mass Index, law.invention, Young Adult, Quality of life, Randomized controlled trial, law, Internal medicine, Diabetes mellitus, Epidemiology, Internal Medicine, medicine, Humans, Epidemiology/Health Services Research, Original Research, Glycated Hemoglobin, Advanced and Specialized Nursing, Type 1 diabetes, business.industry, medicine.disease, Surgery, Diabetes Mellitus, Type 1, Erectile dysfunction, Cohort, Quality of Life, Female, business, Body mass index |
| الوصف: | OBJECTIVE To examine the long-term effects of type 1 diabetes treatment, metabolic control, and complications on health-related quality of life (HRQOL). RESEARCH DESIGN AND METHODS A total of 1,441 participants, initially 13–39 years of age, were followed for an average of 23.5 years as part of the Diabetes Control and Complications Trial (DCCT) and the Epidemiology of Diabetes Interventions and Complications (EDIC) follow-up study. The Diabetes Quality-of-Life questionnaire (DQOL) was administered annually during DCCT and every other year during EDIC. Biomedical data, including HbA1c levels, exposure to severe hypoglycemia, intercurrent psychiatric events, and development of diabetes complications were collected at regular intervals throughout the follow-up. RESULTS Mean total DQOL scores were not significantly different between the former DCCT intensive and conventional treatment groups (DCCT baseline, 78 ± 8 vs. 78 ± 9; EDIC year 17, 75 ± 11 vs. 74 ± 11). Over the course of the study, a drop of ≥5 points in DQOL score from DCCT baseline maintained on two successive visits occurred in 755 individuals and was associated with increased HbA1c, albumin excretion rate, mean blood pressure, BMI, and occurrence of hypoglycemic events requiring assistance. Lower DQOL scores after 23.5 years of follow-up were associated with prior development of retinopathy (P = 0.0196), nephropathy (P = 0.0019), and neuropathy (P < 0.0001) as well as self-reported chest pain (P = 0.0004), decreased vision in both eyes (P = 0.0005), painful paresthesias (P < 0.0001), recurrent urinary incontinence (P = 0.0001), erectile dysfunction (P < 0.0001), and history of psychiatric events (P < 0.0001). CONCLUSIONS Among DCCT/EDIC participants, worsening metabolic control, serious diabetes complications and their associated symptoms, and development of psychiatric conditions led to decreased HRQOL. |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3b5e980d711d55eed4f5676a08278eTest https://doi.org/10.2337/dc12-2109Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4c3b5e980d711d55eed4f5676a08278e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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