Introducing Genes With Significant Role in Migraine: An Interactomic Approach
| العنوان: | Introducing Genes With Significant Role in Migraine: An Interactomic Approach |
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| المؤلفون: | Mostafa Rezaei Tavirani, Mona Zamanian Azodi, Reza M. Robati |
| المصدر: | Basic and Clinical Neuroscience, Vol 10, Iss 4, Pp 363-372 (2019) Basic and Clinical Neuroscience |
| بيانات النشر: | Iran University of Medical Sciences, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, Candidate gene, Neurology, Clinical neuroscience, protein interaction maps, Molecular neuroscience, Behavioral neuroscience, medicine.disease, Bioinformatics, lcsh:RC321-571, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Migraine, migraine disorders, Cellular neuroscience, medicine, 030212 general & internal medicine, Neurology (clinical), genes, Gene, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, 030217 neurology & neurosurgery, Research Paper |
| الوصف: | Introduction Migraine is a severe kind of headache with the chance hereditary of 50%. Molecular studies can promote understanding of migraine pathophysiology. One of which is bioinformatics approach that could provide additional information related to the identified biomarkers. Methods In this research, migraine genes are studies in terms of interaction pattern to introduce important individuals. Through STRING database Plug-in in Cytoscape, candidate genes for migraine were retrieved and analyzed by related applications. Based on centrality and action types (expression, activation, and inhibition) genes were screened. Results Numbers of 33 central genes including seven hub-bottlenecks were identified which 70% of central genes were involved in expression action with each other. Activation was dominate action relative to inhibition between the central genes. Conclusion The finding indicates that insulin is the most important gene relative to migraine. It seems regulation of metabolism play critical role in control of migraine. |
| اللغة: | English |
| تدمد: | 2228-7442 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1d1cf4af4f1a73b81b84492c350b75Test http://bcn.iums.ac.ir/article-1-1351-en.htmlTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4c1d1cf4af4f1a73b81b84492c350b75 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22287442 |
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