Hypoglycemia Begets Hypoglycemia: The Order Effect in the ASPIRE In-Clinic Study
| العنوان: | Hypoglycemia Begets Hypoglycemia: The Order Effect in the ASPIRE In-Clinic Study |
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| المؤلفون: | David C. Klonoff, John B. Welsh, Francine R. Kaufman, Ronald L. Brazg, John H. Shin, Timothy S. Bailey, Robert H. Slover, Bruce A. Buckingham, Satish K. Garg |
| المصدر: | Diabetes Technology & Therapeutics. 16:125-130 |
| بيانات النشر: | Mary Ann Liebert Inc, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Order effect, Monitoring, Ambulatory, Hypoglycemia, Lactate analyzer, Insulin Infusion Systems, Endocrinology, Internal medicine, Diabetes mellitus, medicine, Humans, Hypoglycemic Agents, Insulin, Exercise, Glycated Hemoglobin, Cross-Over Studies, business.industry, Basal insulin, medicine.disease, Crossover study, Medical Laboratory Technology, Diabetes Mellitus, Type 1, Treatment Outcome, Area Under Curve, Ambulatory, Female, business |
| الوصف: | The ASPIRE in-clinic study established that automatic suspension of insulin with the threshold suspend (TS) feature reduces the duration of induced hypoglycemia. The study's crossover design allowed the effects of antecedent hypoglycemia to be studied.The study enrolled 50 subjects who exercised until plasma glucose (YSI glucose and lactate analyzer; YSI, Inc., Yellow Springs, OH) reached ≤85 mg/dL. Hypoglycemia was evaluated after the YSI value reached70 mg/dL. In TS experiments, insulin was stopped for 2 h once a sensor glucose (SG) value of ≤70 mg/dL was detected; in control experiments, basal insulin delivery continued. Subjects were randomly assigned to Group A (TS in Period 1; control in Period 2) or Group B (control in Period 1; TS in Period 2). Experiments were separated by 3-10 days.Hypoglycemia was 63.7 min shorter in Period 1 TS experiments (no preceding control experiment) than in Period 2 TS experiments (one or more preceding control experiment(s)) (P0.01). The number of experiments prior to a successful TS experiment was lower for Period 1 than for Period 2 (0.36 ± 0.64 vs. 1.57 ± 0.84; P0.001), as was the cumulative duration of antecedent hypoglycemia (16.6 min vs. 204.6 min; P0.001). The between-groups difference in hypoglycemia duration was not attributable to differences in SG rates of change, the duration of exercise, or area under the curve of70 mg/dL × min in the 2 days before the successful experiment (all P0.3).The TS feature's ability to mitigate hypoglycemia was decreased by an episode or episodes of prolonged antecedent hypoglycemia, suggesting hypoglycemia begets hypoglycemia. The effect of antecedent hypoglycemia should be taken into consideration in the design of future experiments assessing strategies to reduce hypoglycemia. |
| تدمد: | 1557-8593 1520-9156 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bccf8a312c99341a9812fad9fff958dTest https://doi.org/10.1089/dia.2013.0219Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4bccf8a312c99341a9812fad9fff958d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15578593 15209156 |
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