Reduced capillary hydraulic conductivity in skeletal muscle and skin in Type I diabetes: a possible cause for reduced transcapillary fluid absorption during hypovolaemia
| العنوان: | Reduced capillary hydraulic conductivity in skeletal muscle and skin in Type I diabetes: a possible cause for reduced transcapillary fluid absorption during hypovolaemia |
|---|---|
| المؤلفون: | Toste Länne, Henrik Olsen |
| المصدر: | Diabetologia. 43:1178-1184 |
| بيانات النشر: | Springer Science and Business Media LLC, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Capillary action, Endocrinology, Diabetes and Metabolism, Hypovolemia, Blood Pressure, Specific adsorption, Absorption (skin), Capillary Permeability, Electrocardiography, Hydraulic conductivity, Heart Rate, Reference Values, Internal medicine, Internal Medicine, medicine, Humans, Plethysmograph, Muscle, Skeletal, Skin, Chemistry, Skeletal muscle, Capillaries, Plethysmography, Diabetes Mellitus, Type 1, Endocrinology, medicine.anatomical_structure, Circulatory system, medicine.symptom |
| الوصف: | Patients with Type I (insulin-dependent) diabetes mellitus have a reduced transcapillary fluid absorption from skeletal muscle and skin and thus defective plasma volume regulation during hypovolaemia. Our aim was to find whether a defective capillary filtration coefficient or impaired transcapillary driving force are aetiologic factors for this reduction.We investigated 11 diabetic patients (diabetes duration 6.9 +/- 1.1 years, age 26 +/- 1 years), without complications and 12 control subjects (26 +/- 1 years). Their capillary filtration coefficient was measured in the upper arm using a volumetric technique at rest and during lower body negative pressure (LBNP). We calculated the driving force for transcapillary fluid transfer.The increase in heart rate and the decrease in systolic blood pressure during lower body negative pressure were similar in diabetic and control subjects. The resting capillary filtration coefficient was decreased in the diabetic subjects, 0.033 +/- 0.003 vs 0.051 +/- 0.007 ml x 100 ml(-1) x min(-1) x mmHg(-1) (p0.05). During lower body negative pressure, the capillary filtration coefficient increased 35 % in both groups compared with resting capillary filtration coefficient and was still decreased in diabetes; 0.046 +/- 0.004 compared with 0.069 +/- 0.006 ml x 100ml(-1) x min(-1) x mmHg(-1) (p0.01). The established driving force during lower body negative pressure was 1.37 +/- 0.11 vs 1.30 +/- 0.15 mmHg (NS) in diabetic and control subjects, respectively.Our study indicates that a reduced capillary filtration coefficient rather than defective regulation of transcapillary driving force, is the reason for the reduced transcapillary fluid absorption during hypovolaemic circulatory stress found in Type I diabetic patients. |
| تدمد: | 1432-0428 0012-186X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9c790f34821636c593b1511a8f1283Test https://doi.org/10.1007/s001250051510Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4b9c790f34821636c593b1511a8f1283 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320428 0012186X |
|---|