Analysis of Programmed Death-1 in Patients with Psoriatic Arthritis
| العنوان: | Analysis of Programmed Death-1 in Patients with Psoriatic Arthritis |
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| المؤلفون: | Marianne Strazza, Inbar Azoulay-Alfaguter, Adam Mor, Gregg J. Silverman, Jose U. Scher, Michael Peled |
| المصدر: | Inflammation. 38:1573-1579 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, CD3, Programmed Cell Death 1 Receptor, Immunology, Arthritis, Pathogenesis, Young Adult, Psoriatic arthritis, Psoriasis Area and Severity Index, Internal medicine, medicine, Humans, Immunology and Allergy, Cells, Cultured, Aged, biology, business.industry, Arthritis, Psoriatic, Middle Aged, medicine.disease, Rheumatology, Case-Control Studies, Rheumatoid arthritis, biology.protein, Biomarker (medicine), Female, business, Biomarkers |
| الوصف: | Programmed death-1 (PD-1) is an inhibitory co-receptor that is highly expressed in T lymphocytes that has been shown to downregulate inflammatory responses in several inflammatory diseases including systemic lupus erythematosus and rheumatoid arthritis. Yet, the role of PD-1 in psoriatic arthritis (PsA) has not been studied. In order to fill this gap, we measured the expression levels of PD-1 in peripheral T cells from patients with active disease. Twenty patients and fifteen age-matched healthy control subjects were recruited. The percentage of CD3(+)PD-1(+) T cells was measured by flow cytometry. Despite normal concentration of peripheral T cells, the expression levels of PD-1 were significantly higher in patients compared to healthy controls. Interestingly, among the patients, the expression levels inversely correlated with disease activity measured by disease activity scores (DAS28). PD-1 expression levels strongly correlated with the number of tender and swollen joints, but not with C-reactive protein (CRP) levels or psoriasis area and severity index (PASI). Functionally, in vitro ligation of PD-1 receptor in PsA T cells inhibited interleukin-2 (IL-2) secretion, Akt phosphorylation, and Rap1 activation. These findings suggest that PD-1 might serve as a biomarker for disease activity in PsA and highlight the need for additional studies in order to establish the role of PD-1 in PsA pathogenesis. |
| تدمد: | 1573-2576 0360-3997 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b623b04a08f0d2fac683e737858d7c5Test https://doi.org/10.1007/s10753-015-0132-2Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4b623b04a08f0d2fac683e737858d7c5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15732576 03603997 |
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