Perception of a divergent family of phytocytokines by the Arabidopsis receptor kinase MIK2
| العنوان: | Perception of a divergent family of phytocytokines by the Arabidopsis receptor kinase MIK2 |
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| المؤلفون: | Steven Moussu, Huanjie Yang, Freddy Boutrot, Jack Rhodes, Cyril Zipfel, Julia Santiago |
| المساهمون: | University of Zurich, Zipfel, Cyril |
| المصدر: | Nature Communications Nature communications, vol. 12, no. 1, pp. 705 Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021) |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0106 biological sciences, 0301 basic medicine, Arabidopsis, General Physics and Astronomy, Peptide, 580 Plants (Botany), Ligands, Plant Roots, 01 natural sciences, Serine, chemistry.chemical_compound, 10126 Department of Plant and Microbial Biology, Fusarium, Brassinosteroid, Cloning, Molecular, Receptor, Disease Resistance, chemistry.chemical_classification, Multidisciplinary, biology, Kinase, food and beverages, Plants, Genetically Modified, 3100 General Physics and Astronomy, Cell biology, Proteome, Intercellular Signaling Peptides and Proteins, Signal Transduction, Pattern recognition receptors, Science, 1600 General Chemistry, Genetics and Molecular Biology, Receptors, Cell Surface, Protein Serine-Threonine Kinases, Article, General Biochemistry, Genetics and Molecular Biology, Fungal Proteins, 03 medical and health sciences, Immune system, 1300 General Biochemistry, Genetics and Molecular Biology, Tobacco, 10211 Zurich-Basel Plant Science Center, Plant Diseases, Pattern recognition receptors in plants, Arabidopsis Proteins, General Chemistry, biology.organism_classification, 030104 developmental biology, chemistry, Plant signalling, General Biochemistry, Protein Kinases, 010606 plant biology & botany |
| الوصف: | Plant genomes encode hundreds of receptor kinases and peptides, but the number of known plant receptor-ligand pairs is limited. We report that the Arabidopsis leucine-rich repeat receptor kinase LRR-RK MALE DISCOVERER 1-INTERACTING RECEPTOR LIKE KINASE 2 (MIK2) is the receptor for the SERINE RICH ENDOGENOUS PEPTIDE (SCOOP) phytocytokines. MIK2 is necessary and sufficient for immune responses triggered by multiple SCOOP peptides, suggesting that MIK2 is the receptor for this divergent family of peptides. Accordingly, the SCOOP12 peptide directly binds MIK2 and triggers complex formation between MIK2 and the BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) co-receptor. MIK2 is required for resistance to the important root pathogen Fusarium oxysporum. Notably, we reveal that Fusarium proteomes encode SCOOP-like sequences, and corresponding synthetic peptides induce MIK2-dependent immune responses. These results suggest that MIK2 may recognise Fusarium-derived SCOOP-like sequences to induce immunity against Fusarium. The definition of SCOOPs as MIK2 ligands will help to unravel the multiple roles played by MIK2 during plant growth, development and stress responses. Secreted peptides and cell-surface localized receptor kinases allow plants to modify growth and development according to external cues. Here, Rhodes et al. show that the MIK2 receptor perceives the SERINE RICH ENDOGENOUS PEPTIDE (SCOOP) family of phytocytokines and is capable of recognising Fusarium-derived SCOOP-like peptides. |
| وصف الملف: | s41467-021-20932-y.pdf - application/pdf; application/pdf |
| تدمد: | 2041-1723 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1d53313796b8f92b84042ccfc6c4f6Test https://doi.org/10.1038/s41467-021-20932-yTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4b1d53313796b8f92b84042ccfc6c4f6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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