Myrup, B, Hansen, P M, Kofoed-Enevoldsen, A, Feldt-Rasmussen, B, Deckert, T, Jensen, T, Jespersen, J & Kluft, C 1995, ' Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus ', The Lancet, vol. 345, no. 8947, pp. 421-422 . https://doi.org/10.1016/S0140-6736Test(95)90403-4
We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low-molecular-weight heparin. Unfractionated and low-molecular-weight heparin induced a significant reduction in urinary albumin excretion (p=0·04 and p=0·004). The mechanism and clinical relevance is unknown but deserve further attention.
