التفاصيل البيبلوغرافية
العنوان:
Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium
المؤلفون:
Hofer, Edith , Roshchupkin, Gennady V. , Adams, Hieab H. H. , Knol, Maria J. , Lin, Honghuang , Li, Shuo , Zare, Habil , Ahmad, Shahzad , Armstrong, Nicola J. , Satizabal, Claudia L. , Bernard, Manon , Bis, Joshua C. , Gillespie, Nathan A. , Luciano, Michelle , Mishra, Aniket , Scholz, Markus , Teumer, Alexander , Xia, Rui , Jian, Xueqiu , Mosley, Thomas H. , Saba, Yasaman , Pirpamer, Lukas , Seiler, Stephan , Becker, James T. , Carmichael, Owen , Rotter, Jerome I. , Psaty, Bruce M. , Lopez, Oscar L. , Amin, Najaf , van der Lee, Sven J. , Yang, Qiong , Himali, Jayandra J. , Maillard, Pauline , Beiser, Alexa S. , DeCarli, Charles , Karama, Sherif , Lewis, Lindsay , Harris, Mat , Bastin, Mark E. , Deary, Ian J. , Witte, A.Veronica , Beyer, Frauke , Loeffler, Markus , Mather, Karen A. , Schofield, Peter R. , Thalamuthu, Anbupalam , Kwok, John B. , Wright, Margaret J. , Ames, David , Trollor, Julian , Jiang, Jiyang , Brodaty, Henry , Wen, Wei , Vernooij, Meike W , Hofman, Albert , Uitterlinden, André G. , Niessen, Wiro J. , Wittfeld, Katharina , Bülow, Robin , Völker, Uwe , Pausova, Zdenka , Pike, G. Bruce , Maingault, Sophie , Crivello, Fabrice , Tzourio, Christophe , Amouye, Philippe , Mazoyer, Bernard , Neale, Michael C. , Franz, Carol E. , Lyons, Michael J. , Panizzon, Matthew S. , Andreassen, Ole A. , Dale, Anders M. , Logue, Mark , Grasby, Katrina L. , Jahanshad, Neda , Painter, Jodie N. , Colodro-Conde, Lucía , Bralten, Janita , Hibar, Derrek P. , Lind, Penelope A. , Pizzagalli, Fabrizio , Stein, Jason L. , Thompson, Paul M. , Medland, Sarah E. , Ching Christopher, R.K. , McMahon Mary Agnes, B. , Shatokhina, Natalia , Zsembik, Leo C.P. , Agartz, Ingrid , Alhusaini, Saud , Almeida, Marcio A.A. , Alnæs, Dag , Amlien, Inge K. , Andersson, Micael , Ard, Tyler , Ashley-Koch, Allison , Brouwer, Rachel M. , Buimer, Elizabeth E.L. , Bürger, Christian , Cannon, Dara M. , Chakravarty, Mallar , Chen, Qiang , Cheung, Joshua W. , Couvy-Duchesne, Baptiste , Dalvie, Shareefa , de Araujo, Tânia K. , de Zubicaray, Greig I. , de Zwarte, Sonja M.C. , Braber, Anouk den , Doan, Nhat Trung , Dohm, Katharina , Ehrlich, Stefan , Engelbrecht, Hannah-Ruth , Erk, Susanne , Fan, Chun Chieh , Fedko, Iryna O. , Foley, Sonya F. , Ford, Judith M. , Fukunaga, Masaki , Garrett, Melanie E. , Ge, Tian , Giddaluru, Sudheer , Goldman, Aaron L. , Groenewold, Nynke A. , Grotegerd, Dominik , Gurholt, Tiril P. , Gutman, Boris A. , Hansell, Narelle K. , Harris, Mathew A. , Harrison, Marc B. , Haswell, Courtney C. , Hauser, Michael , Herms, Stefan , Heslenfeld, Dirk J. , Ho, New Fei , Hoehn, David , Hoffmann, Per , Holleran, Laurena , Hoogman, Martine , Hottenga, Jouke-Jan , Ikeda, Masashi , Janowitz, Deborah , Jansen, Iris E. , Jia, Tianye , Jockwitz, Christiane , Kanai, Ryota , Kasperaviciute, Dalia , Kaufmann, Tobias , Kelly, Sinead , Kikuchi, Masataka , Klein, Marieke , Knapp, Michael , Knodt, Annchen R. , Krämer, Bernd , Lam, Max , Lancaster, Thomas M. , Lee, Phil H. , Lett, Tristram A. , Lewis, Lindsay B. , Lopes-Cendes, Iscia , Macciardi, Fabio , Marquand, Andre F. , Mathias, Samuel R. , Melzer, Tracy R. , Milaneschi, Yuri , Mirza-Schreiber, Nazanin , Moreira, Jose C.V. , Mühleisen, Thomas W. , Müller-Myhsok, Bertram , Najt, Pablo , Nakahara, Soichiro , Nho, Kwangsik , Olde Loohuis, Loes M. , Orfanos, Dimitri Papadopoulos , Pearson, John F. , Pitcher, Toni L. , Pütz, Benno , Ragothaman, Anjanibhargavi , Rashid, Faisal M. , Ronny, Redlich , Reinbold, Céline S. , Repple, Jonathan , Richard, Geneviève , Riedel, Brandalyn C. , Risacher, Shannon L. , Rocha, Cristiane S. , Mota, Nina Roth , Salminen, Lauren , Saremi, Arvin , Saykin, Andrew J. , Schlag, Fenja , Schmaal, Lianne , Secolin, Rodrigo , Shapland, Chin Yang , Shen, Li , Shin, Jean , Shumskaya, Elena , Sønderby, Ida E. , Sprooten, Emma , Strike, Lachlan T. , Tansey, Katherine E. , Thomopoulos, Sophia I. , Tordesillas-Gutiérrez, Diana , Turner, Jessica A. , Uhlmann, Anne , Vallerga, Costanza Ludovica , der Meer, Dennis van , van Donkelaar, Marjolein M.J. , Eijk, Liza van , van Erp, Theo G.M. , van Haren, Neeltje E.M. , Rooij, Daan van , van Tol, Marie-José , Veldink, Jan H. , Verhoef, Ellen , Walton, Esther , Wang, Mingyuan , Wang, Yunpeng , Wardlaw, Joanna M. , Westlye, Lars T. , Whelan, Christopher D. , Witt, Stephanie H. , Wolf, Christiane , Wolfers, Thomas , Yasuda, Clarissa L. , Zaremba, Dario , Zhang, Zuo , Zhu, Alyssa H. , Zwiers, Marcel P. , Artiges, Eric , Assareh, Amelia A. , Ayesa-Arriola, Rosa , Belger, Aysenil , Brandt, Christine L. , Brown, Gregory G. , Cichon, Sven , Curran, Joanne E. , Davies, Gareth E. , Degenhardt, Franziska , Dietsche, Bruno , Djurovic, Srdjan , Doherty, Colin P. , Espiritu, Ryan , Garijo, Daniel , Gil, Yolanda , Gowland, Penny A. , Green, Robert C. , Häusler, Alexander N. , Heindel, Walter , Ho, Beng-Choon , Hoffmann, Wolfgang U. , Holsboer, Florian , Homuth, Georg , Hosten, Norbert , Jack Jr., Clifford R. , Jang, MiHyun , Jansen, Andreas , Kolskår, Knut , Koops, Sanne , Krug, Axel , Lim, Kelvin O. , Luykx, Jurjen J. , Mathalon, Daniel H. , Mattay, Venkata S. , Matthews, Sarah , Van Son, Jaqueline Mayoral , McEwen, Sarah C. , Melle, Ingrid , Morris, Derek W. , Mueller, Bryon A. , Nauck, Matthias , Nordvik, Jan E. , Nöthen, Markus M. , O’Leary, Daniel S. , Opel, Nils , Paillère Martinot, Marie-Laure , Preda, Adrian , Quinlan, Erin B. , Ratnakar, Varun , Reppermund, Simone , Steen, Vidar M. , Torres, Fábio R. , Veltman, Dick J. , Voyvodic, James T. , Whelan, Robert , White, Tonya , Yamamori, Hidenaga , Alvim, Marina K.M. , Anderson, Tim J. , Arias-Vasquez, Alejandro , Baune, Bernhard T. , Blangero, John , Boomsma, Dorret I. , Brunner, Han G. , Buckner, Randy L. , Buitelaar, Jan K. , Bustillo, Juan R. , Cahn, Wiepke , Calhoun, Vince , Caseras, Xavier , Caspers, Svenja , Cavalleri, Gianpiero L. , Cendes, Fernando , Corvin, Aiden , Crespo-Facorro, Benedicto , Dalrymple-Alford, John C. , Dannlowski, Udo , de Geus, Eco J.C. , Delanty, Norman , Depondt, Chantal , Desrivières, Sylvane , Donohoe, Gary , Espeseth, Thomas , Fernández, Guillén , Fisher, Simon E. , Flor, Herta , Forstner, Andreas J. , Francks, Clyde , Franke, Barbara , Glahn, David C. , Gollub, Randy L. , Grabe, Hans J. , Gruber, Oliver , Håberg, Asta K. , Hariri, Ahmad R. , Hartman, Catharina A. , Hashimoto, Ryota , Heinz, Andreas , Hillegers, Manon H.J. , Hoekstra, Pieter J. , Holmes, Avram J. , Hong, L. Elliot , Hopkins, William D. , Hulshoff Pol, Hilleke E. , Jernigan, Terry L. , Jönsson, Erik G. , Kahn, René S. , Kennedy, Martin A. , Kircher, Tilo T.J. , Kochunov, Peter , Kwok, John B.J. , Hellard, Stephanie Le , Martin, Nicholas G. , Martinot, Jean - Luc , McDonald, Colm , McMahon, Katie L. , Meyer-Lindenberg, Andreas , Morey, Rajendra A. , Nyberg, Lars , Oosterlaan, Jaap , Ophoff, Roel A. , Paus, Tomáš , Penninx, Brenda W.J.H. , Polderman, Tinca J.C. , Posthuma, Danielle , Rietschel, Marcella , Roffman, Joshua L. , Rowland, Laura M. , Sachdev, Perminder S. , Sämann, Philipp G. , Schumann, Gunter , Sim, Kang , Sisodiya, Sanjay M. , Smoller, Jordan W. , Sommer, Iris E. , Pourcain, Beate St , Stein, Dan J. , Toga, Arthur W. , Trollor, Julian N. , Van der Wee, Nic J.A. , Ent, Dennis van’t , Völzke, Henry , Walter, Henrik , Weber, Bernd , Weinberger, Daniel R. , Zhou, Juan , Kremen, William S. , Villringer, Arno , Duijn, Cornelia M. van , Jörgen Grabe, Hans , Longstreth Jr, William T. , Fornage, Myriam , Paus, Tomas , Debette, Stephanie , Ikram, M. Arfan , Schmidt, Helena , Schmidt, Reinhold , Seshadri, Sudha
المساهمون:
ENIGMA consortium
المصدر:
bioRxiv
بيانات النشر:
Cold Spring Harbor Laboratory, 2018.
سنة النشر:
2018
مصطلحات موضوعية:
0303 health sciences , biology , Genetic heterogeneity , Cognition , Hindbrain , Disease , Heritability , Biobank , 03 medical and health sciences , 0302 clinical medicine , medicine.anatomical_structure , Evolutionary biology , Cortex (anatomy) , biology.protein , medicine , Sonic hedgehog , 030217 neurology & neurosurgery , 030304 developmental biology
الوصف:
Cortical thickness, surface area and volumes (MRI cortical measures) vary with age and cognitive function, and in neurological and psychiatric diseases. We examined heritability, genetic correlations and genome-wide associations of cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprised 22,822 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the United Kingdom Biobank. Significant associations were replicated in the Enhancing Neuroimaging Genetics through Meta-analysis (ENIGMA) consortium, and their biological implications explored using bioinformatic annotation and pathway analyses. We identified genetic heterogeneity between cortical measures and brain regions, and 161 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There was enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.
وصف الملف:
application/pdf
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a25426178f0fdeb70f62f3b3c015756Test https://doi.org/10.1101/409649Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....4a25426178f0fdeb70f62f3b3c015756
قاعدة البيانات:
OpenAIRE
