ST2 may not be a useful predictor for incident cardiovascular events, heart failure and mortality
| العنوان: | ST2 may not be a useful predictor for incident cardiovascular events, heart failure and mortality |
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| المؤلفون: | Veikko Salomaa, Stefan Blankenberg, Sebastian Appelbaum, Tanja Zeller, Maria Hughes, Aki S. Havulinna, Frank Kee, Annika Jagodzinski |
| المصدر: | Heart. 100:1715-1721 |
| بيانات النشر: | BMJ, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Population, Receptors, Cell Surface, Risk Assessment, Coronary artery disease, Age Distribution, Predictive Value of Tests, Risk Factors, Internal medicine, Natriuretic Peptide, Brain, medicine, Humans, Prospective Studies, Myocardial infarction, Protein Precursors, Sex Distribution, education, Stroke, Finland, Aged, Heart Failure, education.field_of_study, Framingham Risk Score, business.industry, Proportional hazards model, Incidence, valvular heart disease, Middle Aged, Prognosis, medicine.disease, Interleukin-1 Receptor-Like 1 Protein, Peptide Fragments, Survival Rate, Cardiovascular Diseases, Population Surveillance, Heart failure, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies, Forecasting |
| الوصف: | Objectives We hypothesised that soluble ST2 (sST2) levels can identify people with elevated risk of subsequent cardiovascular disease (CVD) and add to existing risk prediction algorithms. Background ST2 is a receptor for the inflammatory cytokine IL33. Increased sST2 levels have been associated with heart failure and death in acute myocardial infarction patients and in the general population. Methods We measured high-sensitivity sST2 in 8444 men and women (25–74 years) from the FINRISK97 prospective population cohort. Cox proportional hazards modelling evaluated the ability of sST2 to predict fatal and non-fatal heart failure, CVD (coronary heart disease, stroke), diabetes, and death over 15 years follow-up. Discrimination and reclassification statistics for 10-year absolute risks compared the ability of sST2 to improve upon Framingham risk factors (FRF), N-terminal pro-brain natriuretic peptide (NT-proBNP), renal function (eGFR) and prevalent valvular heart disease (VHD). Results sST2 showed suggestive but non-significant associations with heart failure {(HR per 1 SD of log sST2 1.06; 95% CI 0.96 to 1.17 (562 events))}, and with CVD (1.01 95% CI 0.94 to 1.08) (914 events) after adjustment for FRF, NT-proBNP, eGFR and VHD. sST2 significantly predicted death from all causes following similar adjustment ({HR 1.09 (95% CI 1.01 to 1.19) (974 events))}. No improvement in the c-index was observed for models adding sST2 to the risk factors. Conclusions In a healthy general population from Finland, sST2 did not improve long-term prediction of cardiovascular events including heart failure or all-cause mortality. |
| تدمد: | 1468-201X 1355-6037 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f6b179e2b522745163621da48d0246Test https://doi.org/10.1136/heartjnl-2014-305968Test |
| رقم الانضمام: | edsair.doi.dedup.....49f6b179e2b522745163621da48d0246 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1468201X 13556037 |
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