التفاصيل البيبلوغرافية
| العنوان: |
Malignant triton tumors-complete surgical resection and adjuvant radiotherapy associated with improved survival |
| المؤلفون: |
Carman A. Giacomantonio, Yarrow J. McConnell |
| المصدر: |
Journal of Surgical Oncology. 106:51-56 |
| بيانات النشر: |
Wiley, 2012. |
| سنة النشر: |
2012 |
| مصطلحات موضوعية: |
Adult, Male, medicine.medical_specialty, Neurofibromatosis 1, medicine.medical_treatment, Kaplan-Meier Estimate, Nerve Sheath Neoplasms, Humans, Medicine, Rhabdomyosarcoma, Survival rate, Aged, Proportional Hazards Models, Retrospective Studies, Analysis of Variance, Chi-Square Distribution, business.industry, Proportional hazards model, Malignant triton tumor, Confounding Factors, Epidemiologic, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, Immunohistochemistry, Surgery, Survival Rate, Radiation therapy, Treatment Outcome, Oncology, Chemotherapy, Adjuvant, Disease Progression, Resection margin, Female, Radiotherapy, Adjuvant, Neoplasm Grading, Neoplasm Recurrence, Local, business, Nerve sheath neoplasm |
| الوصف: |
Background Malignant triton tumors (MTT) are a rare form of peripheral nerve sheath tumors that follows a particularly aggressive course. Given its rarity, only case reports and small series of patients have been published. Methods A Pubmed search was conducted (1966–2009) using the terms “triton tumor,” “rhabdomyosarcoma,” and “malignant peripheral nerve sheath tumor.” The reference lists of retrieved articles were searched. Cases were included when the diagnosis was clear, the patient underwent surgery, and follow-up data were available. Univariate and multivariate analyses were conducted for predictors of positive resection margin, local recurrence/progression, development of metastases, and mortality. Results A total of 124 cases were included. The overall 5-year survival was 14% and the median time to death was 13 months. The overall local recurrence/progression rate was 50% and the median time to recurrence/progression was 6 months. On multivariate Cox proportional hazards analysis, positive margin status (HR 2.2, P = 0.01), local recurrence/progression (HR 3.1, P = 0.003), and development of metastases (HR 2.6, P = 0.003) were associated with mortality. Adjuvant radiotherapy was associated with improved survival (HR 0.4, P = 0.005). Conclusion Complete surgical resection and adjuvant radiotherapy should be the cornerstones of treatment for MTT. J. Surg. Oncol. 2012; 106:51–56. © 2012 Wiley Periodicals, Inc. |
| تدمد: |
0022-4790 |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c8873e18a7ca1f6298a6e62b428f52Test
https://doi.org/10.1002/jso.23042Test |
| حقوق: |
CLOSED |
| رقم الانضمام: |
edsair.doi.dedup.....49c8873e18a7ca1f6298a6e62b428f52 |
| قاعدة البيانات: |
OpenAIRE |
