Cardiac and Vascular Function in Adolescents and Young Adults with Type 1 Diabetes
| العنوان: | Cardiac and Vascular Function in Adolescents and Young Adults with Type 1 Diabetes |
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| المؤلفون: | Alejandro Peirone, Denis Daneman, Amish Parikh, Elizabeth Berger, Etienne Sochett |
| المصدر: | Diabetes Technology & Therapeutics. 6:129-135 |
| بيانات النشر: | Mary Ann Liebert Inc, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, Male, Pediatrics, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Blood Pressure, Cardiovascular System, Endocrinology, Diabetes mellitus, Humans, Medicine, Young adult, Ultrasonography, Glycated Hemoglobin, Type 1 diabetes, business.industry, Heart, medicine.disease, Lipids, Surgery, Medical Laboratory Technology, Diabetes Mellitus, Type 1, Blood Vessels, Female, business, Vascular function |
| الوصف: | The objective was to prospectively define cardiac and vascular function in adolescents and young adults with type 1 diabetes over a 3-year period. Thirty-three subjects with type 1 diabetes were studied in 1998, and 28 returned for follow-up in 2001. There were 28 controls without diabetes. All subjects underwent ultrasonography of the carotid artery to determine distensibility, compliance, and intimal-medial thickness, as well as echocardiographic studies, lipid profile, and measurement of hemoglobin A1c (HbA1c) levels and urinary albumin excretion rate. The diabetes group showed no significant change over the 3-year follow-up in lipid profile, HbA1c level, or albumin excretion rate, but a significant increase in body mass index. The diabetes and control groups were similar in age, lipid profile, and albumin excretion rate. Carotid artery distensibility and compliance in the diabetes group increased significantly from baseline to follow-up but did not differ significantly from controls. The intimal-medial thickness of the diabetes group remained unchanged over time but tended to be higher than controls. Echocardiographic studies showed no difference between the diabetes and control groups, but there was a small change in left ventricular posterior diastolic wall diameter in the subjects with diabetes over the 3-year period. There was an overall improvement in carotid function and no change in cardiac measures in subjects with diabetes over the 3 years, such that cardiac and vascular function were similar to those of controls. The reason for the improvement is uncertain, but may relate to the improvement of insulin sensitivity at the end of the pubertal growth period, rather than to changes in metabolic control or lipid profiles. |
| تدمد: | 1557-8593 1520-9156 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496003a54abc22f1ecb8fd343cbb0a60Test https://doi.org/10.1089/152091504773731311Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....496003a54abc22f1ecb8fd343cbb0a60 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15578593 15209156 |
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