Effect of gastric distension with concurrent small intestinal saline or glucose infusion on incretin hormone secretion in healthy individuals: A randomized, controlled, crossover study
| العنوان: | Effect of gastric distension with concurrent small intestinal saline or glucose infusion on incretin hormone secretion in healthy individuals: A randomized, controlled, crossover study |
|---|---|
| المؤلفون: | Ryan J. Jalleh, Laurence G. Trahair, Tongzhi Wu, Scott Standfield, Christine Feinle‐Bisset, Christopher K. Rayner, Michael Horowitz, Karen L. Jones |
| المساهمون: | Jalleh, Ryan J, Trahair, Laurence G, Wu, Tongzhi, Standfield, Scott, Feinle Bisset, Christine, Rayner, Christopher K, Horowitz, Michael, Jones, Karen L |
| المصدر: | Diabetes, Obesity and Metabolism. |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | glucose-dependent insulinotropic polypeptide, barostat, Endocrinology, glucagon-like peptide-1, Endocrinology, Diabetes and Metabolism, Internal Medicine, gastric distension, incretin, intragastric balloon |
| الوصف: | Aim: To evaluate the effect of gastric distension, induced using a gastric ‘barostat’, on the secretion of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) in the presence and absence of small intestinal nutrients in healthy individuals. Materials and Methods: Eight healthy participants (two females, six males, mean age 69.3 ± 1.2 years, body mass index 23.5 ± 0.8 kg/m2) were each studied on four occasions when they received an intraduodenal infusion of either (i) 0.9% saline or (ii) glucose delivered at a rate of 3 kcal/min both with, and without, an intragastric balloon with the pressure set to 8 mmHg above the intragastric minimum distending pressure. Results: Following intraduodenal saline or glucose infusion, there was no difference in plasma GLP-1 with or without gastric distension (P = 1.00 for both saline and glucose infusions). There was also no difference in plasma GIP with or without gastric distension (P = 1.00 for saline infusion and P = .99 for glucose infusion). Conclusions: Gastric distension, either alone or during small intestinal glucose exposure, does not stimulate incretin hormone secretion significantly in healthy humans. Refereed/Peer-reviewed |
| تدمد: | 1463-1326 1462-8902 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490cb4785991a36c5a7435a6aa6ca101Test https://doi.org/10.1111/dom.15042Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....490cb4785991a36c5a7435a6aa6ca101 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14631326 14628902 |
|---|