Autoimmune manifestations in patients with multiple myeloma and monoclonal gammopathy of undetermined significance
| العنوان: | Autoimmune manifestations in patients with multiple myeloma and monoclonal gammopathy of undetermined significance |
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| المؤلفون: | Constantin A Dasanu, Alexei Shimanovsky, Shruti Murali, Argote J. Alvarez |
| المصدر: | BBA Clinical |
| بيانات النشر: | Elsevier BV, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | business.industry, Review Article, medicine.disease, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, 030220 oncology & carcinogenesis, Physiology (medical), Immunology, Molecular Medicine, Medicine, In patient, business, Multiple myeloma, Monoclonal gammopathy of undetermined significance, 030215 immunology |
| الوصف: | Background Multiple myeloma (MM) and its precursor, monoclonal gammopathy of undetermined significance (MGUS), have been linked with several autoimmune conditions in the medical literature. Yet, significance of these associations is not well understood. Methods Herein, we provide a comprehensive literature review on autoimmune disorders identified in patients with MM and MGUS. Most relevant papers were identified via searching the PubMed/Medline and EMBASE databases for articles published from inception until May 1, 2016. Findings Scientific literature on autoimmune conditions in patients with MM and MGUS consists of several case series and a multitude of case reports. Our analysis suggests an increased prevalence of autoimmune conditions in patients with MM and monoclonal gammopathy of undetermined significance (MGUS), including various autoimmune hematologic and rheumatologic conditions among other entities. Conversely, persons with various autoimmune conditions tend to have a higher prevalence of MGUS and MM than the general population. Conclusions Future research is required to explore further the link between MGUS/MM and autoimmune disorders. Inflammation in the setting of autoimmunity may serve as a trigger for MGUS and MM. In addition, a common genetic susceptibility for developing both an autoimmune disease and MM/MGUS might also exist. Autoimmune hematologic and rheumatologic diseases may pose important clinical problems for the MM patients. Therefore, a catalogue of these problems is important so that physicians are able to consider, identify and address them promptly. Highlights • A comprehensive review linking MM and MGUS with autoimmune disorders • There is increased prevalence of autoimmune conditions in patients with MM and MGUS • Most autoimmune disorders precede the development of plasma cell dyscrasias |
| تدمد: | 2214-6474 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c7b5e5a20f7d32ae48ed32d4151778Test https://doi.org/10.1016/j.bbacli.2016.05.004Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....47c7b5e5a20f7d32ae48ed32d4151778 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22146474 |
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