Accumulation of advanced glycation end products in the skin is accelerated in relation to insulin resistance in people with Type 1 diabetes mellitus
| العنوان: | Accumulation of advanced glycation end products in the skin is accelerated in relation to insulin resistance in people with Type 1 diabetes mellitus |
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| المؤلفون: | Agnieszka Gandecka, Aleksandra Araszkiewicz, Aleksandra Uruska, Dorota Zozulińska-Ziółkiewicz |
| المصدر: | Diabetic Medicine. 36:620-625 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Glycation End Products, Advanced, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Disease duration, 030209 endocrinology & metabolism, Fluorescence, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Insulin resistance, Predictive Value of Tests, Risk Factors, Glycation, Interquartile range, Internal medicine, Internal Medicine, Humans, Medicine, 030212 general & internal medicine, Skin, Glycated Hemoglobin, Type 1 diabetes, business.industry, Optical Imaging, Skin autofluorescence, Middle Aged, medicine.disease, Autofluorescence, Diabetes Mellitus, Type 1, Glucose, Female, Insulin Resistance, Negative correlation, business, Diabetic Angiopathies |
| الوصف: | AIM To evaluate the association between skin advanced glycation end products and insulin resistance in Type 1 diabetes. METHODS The study group consisted of 476 people with Type 1 diabetes (247 men) with a median (interquartile range) age of 42 (33-53) years, disease duration of 24 (19-32) years and HbA1c concentration of 63 (55-74) mmol/mol [7.9 (7.2-8.9)%]. Insulin resistance was assessed according to estimated glucose disposal rate. Advanced glycation product accumulation in the skin was measured by autofluorescence using an AGE Reader. The group was divided into three subgroups based on estimated glucose disposal rate tertiles ( 9.5 mg/kg/min, respectively). The higher the estimated glucose disposal rate, the lower the insulin resistance. RESULTS Skin autofluoresence level decreased with increasing estimated glucose disposal rate; comparing people below the lower tertile, with those between the first and third tertiles, and with those above the third tertile, the median autofluoresences were, respectively: 2.5 (2.2-2.9) vs 2.3 (2.0-2.7) vs 2.1 (1.9-2.5) AU (P |
| تدمد: | 1464-5491 0742-3071 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b4c57402df97e9aee50ffdbeca48e0Test https://doi.org/10.1111/dme.13921Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....47b4c57402df97e9aee50ffdbeca48e0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14645491 07423071 |
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