Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma
| العنوان: | Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma |
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| المؤلفون: | Kirsi-Maria Haapasaari, Joel Isohookana, Heikki Huhta, Joni Leppänen, Joonas H. Kauppila, Seppo Parkkila, Tuomo J. Karttunen, Juha Saarnio, Petri Lehenkari, Olli Helminen |
| المساهمون: | Lääketieteen ja biotieteiden tiedekunta - Faculty of Medicine and Life Sciences, University of Tampere |
| المصدر: | World Journal of Surgical Oncology, Vol 16, Iss 1, Pp 1-9 (2018) World Journal of Surgical Oncology |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Adult, Male, medicine.medical_specialty, Poor prognosis, Pancreatic ductal adenocarcinoma, Stromal cell, Biolääketieteet - Biomedicine, lcsh:Surgery, Carbonic anhydrase 9, Northern finland, Adenocarcinoma, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, Surgical oncology, Internal medicine, medicine, Biomarkers, Tumor, Humans, Carbonic Anhydrase IX, Finland, Aged, business.industry, Research, HIF-1 alpha, HIF-1alpha, lcsh:RD1-811, Hypoxia (medical), Middle Aged, Hypoxia-Inducible Factor 1, alpha Subunit, Prognosis, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Immunohistochemistry, 030104 developmental biology, 030220 oncology & carcinogenesis, Surgery, Female, medicine.symptom, business, Carcinoma, Pancreatic Ductal |
| الوصف: | Background HIF-1alpha and CAIX proteins are commonly expressed under hypoxic conditions, but other regulatory factors have been described as well. Pancreatic ductal adenocarcinoma (PDAC) is characterized by hypoxia and strong stromal reaction and has a dismal prognosis with the currently available treatment modalities. Methods We investigated the expression and prognostic role of HIF-1alpha and CAIX in PDAC series from Northern Finland (n = 69) using immunohistochemistry. Results In our PDAC cases, 95 and 85% showed HIF-1alpha and CAIX expression, respectively. Low HIF-1alpha expression correlated with poor prognosis, and multivariate analysis identified weak HIF-1alpha intensity as an independent prognostic factor for PDAC-specific deaths (HR 2.176, 95% CI 1.216–3.893; p = 0.009). There was no correlation between HIF-1alpha and CAIX expression levels, and the latter did not relate with survival. Conclusions Our findings are in contrast with previous research by finding an association between low HIF-1alpha and poor prognosis. The biological mechanisms remain speculative, but such an unexpected relation with prognosis and absence of correlation between HIF-1alpha and CAIX suggests that the prognostic association of HIF-1alpha may not directly be linked with hypoxia. Accordingly, the role of HIF-1alpha might be more complex than previously thought and the use of this marker as a hypoxia-related prognostic factor should be addressed with caution. Electronic supplementary material The online version of this article (10.1186/s12957-018-1432-4) contains supplementary material, which is available to authorized users. |
| وصف الملف: | fulltext; application/pdf |
| اللغة: | English |
| تدمد: | 1477-7819 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470111c33216a6aa4d77aecf2964c917Test http://link.springer.com/article/10.1186/s12957-018-1432-4Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....470111c33216a6aa4d77aecf2964c917 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14777819 |
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