Identification of a Novel HIV-1 B/C/CRF01_AE Recombinant Isolate in Guangxi, China
| العنوان: | Identification of a Novel HIV-1 B/C/CRF01_AE Recombinant Isolate in Guangxi, China |
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| المؤلفون: | Desheng Kong, Yan Wang, Chen Wang, Liying Ma, Yi Feng, Shujia Liang |
| المصدر: | AIDS Research and Human Retroviruses. 34:635-639 |
| بيانات النشر: | Mary Ann Liebert Inc, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, China, medicine.medical_specialty, Genotype, viruses, Human Immunodeficiency Virus Proteins, Immunology, Human immunodeficiency virus (HIV), HIV Infections, Biology, medicine.disease_cause, Recombinant virus, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Virology, Molecular genetics, medicine, Humans, 030212 general & internal medicine, Gene, Recombination, Genetic, Genetics, Genetic diversity, Whole Genome Sequencing, virus diseases, Middle Aged, Viral Tropism, 030104 developmental biology, Infectious Diseases, HIV-1, Recombinant DNA, Female, Identification (biology), human activities |
| الوصف: | Continual generation of HIV-1 recombinant forms might contribute to its genetic diversity. In this study, a novel B/C/CRF01_AE recombinant virus (GX2016EU13) was identified, which was isolated from a HIV-positive man who was infected through heterosexual sex in Guangxi, China. GX2016EU13 was identified as CCR5-tropic. As shown in the near full-length genome (NFLG) analyses, five recombinant breakpoints were found only in the pol gene of GX2016EU13, which divided the NFLG into three subtype B segments, two subtype C segments, and one CRF01_AE segment. The whole gag sequence of GX2016EU13 belongs to subtype B, and the whole env sequence of GX2016EU13 belongs to CRF01_AE. The recombinant form was distinct from the other circulating recombinant forms and unique recombinant forms reported. The emergence of GX2016EU13 may suppose the complexity of the HIV-1 epidemic in high-risk sexual populations in Guangxi, China. |
| تدمد: | 1931-8405 0889-2229 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c411d24b66f4331813173ecf212a63Test https://doi.org/10.1089/aid.2018.0070Test |
| رقم الانضمام: | edsair.doi.dedup.....46c411d24b66f4331813173ecf212a63 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19318405 08892229 |
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