Preconception Exposure to Fine Particulate Matter Leads to Cardiac Dysfunction in Adult Male Offspring
| العنوان: | Preconception Exposure to Fine Particulate Matter Leads to Cardiac Dysfunction in Adult Male Offspring |
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| المؤلفون: | Jacob A. Grimmer, Aashish Katapadi, Lisa A. Baer, Benjamin P. Sugar, Michael J. Falvo, Loren E. Wold, Dane J. Youtz, Kristin I. Stanford, Vineeta Tanwar, Jeremy M. Adelstein |
| المصدر: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Adult male, Fine particulate, Myocardial Biology, Physiology, 030204 cardiovascular system & hematology, Calcium Cycling/Excitation-Contraction Coupling, Ventricular Function, Left, Epigenesis, Genetic, Mice, Ventricular Dysfunction, Left, 0302 clinical medicine, Risk Factors, Medicine, Myocyte, Myocytes, Cardiac, Original Research, myocyte, Inhalation Exposure, preconception, Gene Expression Regulation, Developmental, Particulates, 3. Good health, Maternal Exposure, In utero, Paternal Exposure, Female, Inflammation Mediators, medicine.symptom, Cardiology and Cardiovascular Medicine, Offspring, Inflammation, Pathophysiology, Risk Assessment, Cardiac dysfunction, 03 medical and health sciences, Sex Factors, Animals, Calcium Signaling, Particle Size, cardiovascular function, Heart Failure, calcium, business.industry, Correction, Stroke Volume, Myocardial Contraction, Oxidative Stress, 030104 developmental biology, Animal Models of Human Disease, Preconception Injuries, inflammation, Particulate Matter, Contractile function, business |
| الوصف: | Background Particulate matter (particles < 2.5 μm [PM 2.5]) exposure during the in utero and postnatal developmental periods causes cardiac dysfunction during adulthood. Here, we investigated the potential priming effects of preconception exposure of PM 2.5 on cardiac function in adult offspring. Methods and Results Male and female friend leukemia virus b (FVB) mice were exposed to either filtered air (FA) or PM 2.5 at an average concentration of 38.58 μg/m3 for 6 hours/day, 5 days/week for 3 months. Mice were then crossbred into 2 groups: (1) FA male×FA female (both parents were exposed to FA preconception) and, (2) PM 2.5male×PM 2.5female (both parents were exposed to PM 2.5 preconception). Male offspring were divided: (1) preconception FA (offspring born to FA exposed parents) and, (2) preconception PM 2.5 (offspring born to PM 2.5 exposed parents) and analyzed at 3 months of age. Echocardiography identified increased left ventricular end systolic volume and reduced posterior wall thickness, reduced %fractional shortening and %ejection fraction in preconception PM 2.5 offspring. Cardiomyocytes isolated from preconception PM 2.5 offspring showed reduced %peak shortening, −dL/dT, TPS90 and slower calcium reuptake (tau). Gene and protein expression revealed modifications in markers of inflammation (IL‐6, IL‐15, TNFα, NFқB, CRP, CD26E, CD26P, intercellular adhesion molecule 1, and monocyte chemoattractant protein‐1) profibrosis (collagen type III alpha 1 chain), oxidative stress (NOS2), antioxidants (Nrf2, SOD, catalase), Ca2+ regulatory proteins (SERCA2a, p‐PLN, NCX), and epigenetic regulators (Dnmt1, Dnmt3a, Dnmt3b, Sirt1, and Sirt2) in preconception PM 2.5 offspring. Conclusions Preconception exposure to PM 2.5 results in global cardiac dysfunction in adult offspring, suggesting that abnormalities during development are not limited to the prenatal or postnatal periods but can also be determined before conception. See Editorial by Stapleton |
| تدمد: | 2047-9980 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4597ea4cb0e1fdeff4e0fc30c7b7d7dcTest https://doi.org/10.1161/jaha.118.010797Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4597ea4cb0e1fdeff4e0fc30c7b7d7dc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20479980 |
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