In vivo modulation of N-myristoyltransferase activity by orthovanadate
| العنوان: | In vivo modulation of N-myristoyltransferase activity by orthovanadate |
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| المؤلفون: | Ramji L. Khandelwal, Martin J. King, Rajendra K. Sharma, Subbiah Pugazhenthi |
| المصدر: | Molecular and Cellular Biochemistry. 153:151-155 |
| بيانات النشر: | Springer Science and Business Media LLC, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | medicine.medical_specialty, endocrine system diseases, Clinical chemistry, medicine.medical_treatment, Clinical Biochemistry, Diabetes Mellitus, Experimental, chemistry.chemical_compound, In vivo, Internal medicine, Diabetes mellitus, medicine, Animals, Vanadate, Molecular Biology, Sodium orthovanadate, business.industry, Insulin, nutritional and metabolic diseases, Cell Biology, General Medicine, medicine.disease, Rats, Rats, Zucker, Endocrinology, Diabetes Mellitus, Type 2, Liver, chemistry, Glycine, Vanadates, Signal transduction, business, Acyltransferases |
| الوصف: | N-Myristoyltransferase (NMT) catalyses the transfer of myristate from myristoyl-CoA to the NH2-terminal glycine residue of several proteins and are important in signal transduction. STZ-induced diabetes (an animal model for insulin-dependent diabetes mellitus, IDDM) resulted in a 2-fold increase in rat liver NMT activity as compared with control animals. In obese Zucker (fa/fa) rats (an animal model for non-insulin dependent diabetes mellitus, NIDDM) there was a approximately 4.7-fold lower liver particulate NMT activity as compared with the control lean rat livers. Administration of sodium orthovanadate to the diabetic rats normalised liver NMT activity. These results would indicate that the rat liver particulate N-myristoyltransferase activity appears to be inversely proportional to the level of plasma insulin, implicating insulin in the control of N-myristoylation. |
| تدمد: | 1573-4919 0300-8177 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452e177d24ffd93cd99cc97267e9948dTest https://doi.org/10.1007/bf01075931Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....452e177d24ffd93cd99cc97267e9948d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15734919 03008177 |
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