Skeletal muscle unloading results in increased mitophagy and decreased mitochondrial biogenesis regulation
| العنوان: | Skeletal muscle unloading results in increased mitophagy and decreased mitochondrial biogenesis regulation |
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| المؤلفون: | Lex B. Verdijk, Pieter A. Leermakers, Chiel C. de Theije, Anita Kneppers, Harry R. Gosker, Marco C. J. M. Kelders, Luc J. C. van Loon, Annemie M. W. J. Schols, Ramon C. J. Langen |
| المساهمون: | RS: NUTRIM - R3 - Respiratory & Age-related Health, Promovendi NTM, Pulmonologie, Ondersteunend personeel NTM, Humane Biologie, Physiotherapy, Human Physiology and Anatomy, Human Physiology and Sports Physiotherapy Research Group |
| المصدر: | Muscle & Nerve, 60(6), 769-778. Wiley Muscle & Nerve |
| بيانات النشر: | John Wiley & Sons Inc., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, DYNAMICS, mitochondrial biogenesis, Physiology, Gene Expression, 030105 genetics & heredity, Mitochondrion, Quadriceps Muscle, Weight-Bearing, ACTIVATION, Mice, 0302 clinical medicine, Mitophagy, Organelle Biogenesis, SOLEUS MUSCLE, Chemistry, muscle unloading, Cell biology, mitochondria, medicine.anatomical_structure, Hindlimb Suspension, inactivity, Adult, FUNDC1, GENES, Adolescent, Vastus lateralis muscle, Muscle mass, ATROPHY, Immobilization, Young Adult, 03 medical and health sciences, Cellular and Molecular Neuroscience, Gastrocnemius muscle, Basic Science Research Articles, Physiology (medical), medicine, Basic Science Research Article, Animals, Humans, skeletal muscle, Muscle, Skeletal, LEG IMMOBILIZATION, Skeletal muscle, PATHWAYS, Mitochondria, Muscle, Mice, Inbred C57BL, OVER-EXPRESSION, Casts, Surgical, mitophagy, Mitochondrial biogenesis, YOUNG, Neurology (clinical), 030217 neurology & neurosurgery, Biogenesis |
| الوصف: | IntroductionPhysical inactivity significantly contributes to loss of muscle mass and performance in bed-bound patients. Loss of skeletal muscle mitochondrial content has been well-established in muscle unloading models, but the underlying molecular mechanism remains unclear. We hypothesized that apparent unloading-induced loss of muscle mitochondrial content is preceded by increased mitophagy- and decreased mitochondrial biogenesis-signaling during the early stages of unloading.MethodsWe analyzed a comprehensive set of molecular markers involved in mitochondrial-autophagy, -biogenesis, -dynamics, and -content, in the gastrocnemius muscle of C57BL/6J mice subjected to 0- and 3-days hind limb suspension, and in biopsies from human vastus lateralis muscle obtained before and after 7days of one-leg immobilization.ResultsIn both mice and men, short-term skeletal muscle unloading results in molecular marker patterns indicative of increased receptor-mediated mitophagy and decreased mitochondrial biogenesis regulation, before apparent loss of mitochondrial content.DiscussionThese results emphasize the early-onset of skeletal muscle disuse-induced mitochondrial remodeling. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0148-639X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4519c8f7096615dd2467c36cf1d566a2Test https://acuresearchbank.acu.edu.au/item/86qv9/skeletal-muscle-unloading-results-in-increased-mitophagy-and-decreased-mitochondrial-biogenesis-regulationTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4519c8f7096615dd2467c36cf1d566a2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0148639X |
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