Poor glycaemic control contributes to a shift towards prothrombotic and antifibrinolytic state in pregnant women with type 1 diabetes mellitus
| العنوان: | Poor glycaemic control contributes to a shift towards prothrombotic and antifibrinolytic state in pregnant women with type 1 diabetes mellitus |
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| المؤلفون: | Ewa Wender-Ozegowska, Urszula Mantaj, Maciej Osiński, Paweł Gutaj, Malgorzata Kedzia |
| المصدر: | PLoS ONE PLoS ONE, Vol 15, Iss 10, p e0237843 (2020) |
| بيانات النشر: | Public Library of Science (PLoS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Blood Glucose, Physiology, Maternal Health, Pregnancy in Diabetics, Blood Pressure, Cardiovascular Medicine, 030204 cardiovascular system & hematology, Biochemistry, Vascular Medicine, Endocrinology, Medical Conditions, 0302 clinical medicine, Pregnancy, Animal Cells, Medicine and Health Sciences, Diabetes diagnosis and management, 030212 general & internal medicine, Multidisciplinary, Fibrinolysis, Area under the curve, Obstetrics and Gynecology, Hematology, Body Fluids, Blood, Cardiovascular Diseases, Cardiology, Medicine, Female, Blood Coagulation Tests, Anatomy, Cellular Types, Research Article, Adult, Platelets, medicine.medical_specialty, HbA1c, Antifibrinolytic, Endocrine Disorders, medicine.drug_class, Science, Young Adult, 03 medical and health sciences, Diabetes mellitus, Internal medicine, Diabetes Mellitus, medicine, Humans, Hemoglobin, Mean platelet volume, Thrombus, Glycemic, Hemostasis, Type 1 diabetes, Blood Cells, business.industry, Biology and Life Sciences, Proteins, Thrombosis, Cell Biology, Cardiovascular Disease Risk, medicine.disease, Diagnostic medicine, Diabetes Mellitus, Type 1, Case-Control Studies, Metabolic Disorders, Women's Health, Poland, business |
| الوصف: | OjectivesThrombotic and antifibrinolytic influence of Diabetes mellitus type 1 (T1DM) on haemostasis have been well demonstrated. There has been no research assessing the influence of poor glycemic control on thrombus formation under flow conditions in vitro or in pregnant type 1 diabetic women to date.Patients/methodsThis study compared singleton pregnant T1DM women (n = 21) and control pregnant subjects without any metabolic disease (n = 15). The T1DM group was divided into two subgroups of sufficient (SGC-DM; HbA1c ≤6,5%,n = 15) and poor glycaemic control (PGC-DM; HbA1c >6,5%,n = 6). Evaluation of the whole blood thrombogenicity we assessed using T-TAS® at a shear rate of 240 s-1 (Total-Thrombus Analysis System, Zacros, Japan).ResultsBlood clot formation initiation time (T10) was significantly shortened in PGC-DM subgroup when compared to SGC-DM subgroup (p = 0,03). The area under the curve (AUC30) of blood clot time formation and the MPV (mean platelet volume) values were substantially higher in the PGC-DM subgroup in comparison to the SGC-DM group (p = 0,03). Negative correlations were noted between HbA1c and T10 values (p = 0,02) and between T10 and MPV values in the T1DM group (p = 0,04).ConclusionsPoor glycaemic control in T1DM subjects triggers a shift towards a prothrombotic and antifibrinolytic state. This phenomenon can be detected using the novel system for quantitative assessment of the platelet thrombus formation process under flow conditions in vitro. The alteration of T-TAS values in PGC-DM subgroup proves that a poor glycemic control-related shift of the equilibrium toward thrombogenesis occurs in this group of patients. Our findings need a further elucidation in research on more massive data sets to be confirmed. |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449deef563a26b0e54f69810d3b35e12Test https://doi.org/10.1371/journal.pone.0237843Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....449deef563a26b0e54f69810d3b35e12 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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