The interplay between cell signalling and the mevalonate pathway in cancer
| العنوان: | The interplay between cell signalling and the mevalonate pathway in cancer |
|---|---|
| المؤلفون: | Peter J. Mullen, Rosemary Yu, Michael C. Archer, Joseph Longo, Linda Z. Penn |
| المصدر: | Nature Reviews Cancer. 16:718-731 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Cell signaling, animal structures, viruses, General Mathematics, Mevalonic Acid, Biology, complex mixtures, 03 medical and health sciences, Neoplasms, medicine, Humans, Applied Mathematics, Cancer, hemic and immune systems, Metabolism, medicine.disease, Cell biology, Metabolic pathway, 030104 developmental biology, Cancer metabolism, Mevalonate pathway, Signal transduction, Signalling pathways, Metabolic Networks and Pathways, Signal Transduction |
| الوصف: | The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to produce sterols and isoprenoids that are integral to tumour growth and progression. In recent years, many oncogenic signalling pathways have been shown to increase the activity and/or the expression of MVA pathway enzymes. This Review summarizes recent advances and discusses unique opportunities for immediately targeting this metabolic vulnerability in cancer with agents that have been approved for other therapeutic uses, such as the statin family of drugs, to improve outcomes for cancer patients. |
| تدمد: | 1474-1768 1474-175X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44579fb2e893e634174ba9ab66ffe337Test https://doi.org/10.1038/nrc.2016.76Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....44579fb2e893e634174ba9ab66ffe337 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14741768 1474175X |
|---|