Preparation and Properties of 3-Halopyridine-adenine Dinucleotides, NAD + Analogues and of Model Compounds
| العنوان: | Preparation and Properties of 3-Halopyridine-adenine Dinucleotides, NAD + Analogues and of Model Compounds |
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| المؤلفون: | Jean-Pierre Samama, Mohamed A. Abdallah, Anthony D. Wrixon, Jean-François Biellmann |
| المصدر: | European Journal of Biochemistry. 64:351-360 |
| بيانات النشر: | Wiley, 1976. |
| سنة النشر: | 1976 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Magnetic Resonance Spectroscopy, biology, Adenine Nucleotides, Stereochemistry, Molecular Conformation, Substrate (chemistry), Alcohol, NAD, Biochemistry, Malate dehydrogenase, Cinnamaldehyde, Alcohol Oxidoreductases, Kinetics, chemistry.chemical_compound, Enzyme, Liver, chemistry, Lactate dehydrogenase, biology.protein, Animals, Spectrophotometry, Ultraviolet, Horses, NAD+ kinase, Alcohol dehydrogenase |
| الوصف: | The preparation of model compounds 1-(2',6'-dichlorobenzyl)-3-halogenopyridinium and the study of their properties were achieved. Their chemical reduction to the corresponding 1,4-dihydropyridines is proved by spectroscopic analysis. 3-Iodopyridine--adenine dinucleotide was prepared by enzymic transglycosidation while the 3-chloro, 3-bromo and 3-iodo pyridine--adenine dinucleotides were synthesized from 3-amino-pyridine--adenine dinucleotide. The 3-halogenopyridine--adenine dinucleotides were proved to be active as hydrogen acceptors with alcohol as a substrate. The absorption band at 290 nm of cinnamaldehyde appeared to be a very sensitive tool for studying the enzymic reaction. With the alcohol dehydrogenase from yeast, only slight activity was detected. 3-Halogenopyridine--adenine dinucleotides are competitive inhibitors with respect to nicotinamide--adenine dinucleotide with alcohol dehydrogenase from yeast, lactate dehydrogenase and malate dehydrogenase. The use of 3-iodopyridine--adenine dinucleotide as a heavy-atom derivative for X-ray structure determination is proposed. |
| تدمد: | 1432-1033 0014-2956 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440ff3e379d822d024bba7af186dd94fTest https://doi.org/10.1111/j.1432-1033.1976.tb10308.xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....440ff3e379d822d024bba7af186dd94f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321033 00142956 |
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