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Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference

التفاصيل البيبلوغرافية
العنوان: Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference
المؤلفون: Munteanu, M., Tiniakos, D., Anstee, Q., Charlotte, F., Marchesini, G., Bugianesi, E., Trauner, M., Romero Gomez, M., Oliveira, C., Day, C., Dufour, J.‐F., Bellentani, S., Ngo, Y., Traussnig, S., Perazzo, H., Deckmyn, O., Bedossa, P., Ratziu, V., Poynard, T., Ratziu, Vlad, Poynard, Thierry, Castille, Jean‐Marie, Ngo, Yen, Langon, Tania, Day, Chris, Tiniakos, Dina, Lawlor, Debbie, Marchesini, Giulio, Marra, Fabio, Bugianesi, Elisabetta, Bellentani, Stefano, Dufour, Jean‐François, Romero Gomez, Manuel, Sørensen, Thorkild, Tribelli, Claudio, De Minicis, Samuele, Trauner, Michael, Oliveira, Claudia, Bedossa, Pierre, Burt, Alastair D., Gouw, Annette S.H., Lackner, Carolin, Schirmacher, Peter, Terracciano, Luigi, Brain, J., Bury, Yvonne, Cabibi, Daniela, Charlotte, Frederic, David, Ezio, Losi, Luisa, Montani, Matteo, Pareja, Marıa Jesus, Wendum, Dominique, Wrba, Fritz, Ziol, Marianne, Thabut, Dominique, Moussalli, Joseph, Lebray, Pascal, Rudler, Marika, Bismuth, Françoise Imbert, Rosmorduc, Olivier, Calmus, Yvon, Hartemann, Agnes, Jacqueminet, Sophie, Bruckert, Eric, Giral, Philippe, Naveau, Sylvie, Perlemuter, Gabriel, Varsat, Brigitte, Mercadier, Anne
المساهمون: Biopredictive, National and Kapodistrian University of Athens (NKUA), Newcastle University [Newcastle], Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Università degli studi di Torino (UNITO), Medizinische Universität Wien = Medical University of Vienna, Universidad de Sevilla, University of São Paulo School of Medicine, Universität Bern [Bern], Università degli Studi di Modena e Reggio Emilia (UNIMORE), Université Pierre et Marie Curie - Paris 6 (UPMC), Hôpital Beaujon, Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), National and Kapodistrian University of Athens = University of Athens (NKUA | UoA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP], Università di Bologna [Bologna] (UNIBO), Hôpital Beaujon-Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Munteanu, M., Tiniakos, D., Anstee, Q., Charlotte, F., MARCHESINI REGGIANI, Giulio, Bugianesi, E., Trauner, M., Romero Gomez, M., Oliveira, C., Day, C., Dufour, J. F., Bellentani, S., Ngo, Y., Traussnig, S., Perazzo, H., Deckmyn, O., Bedossa, P., Ratziu, V., Poynard, T., Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Università degli studi di Torino = University of Turin (UNITO), Universidad de Sevilla / University of Sevilla, Universität Bern [Bern] (UNIBE), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
المصدر: Alimentary Pharmacology and Therapeutics
Alimentary Pharmacology and Therapeutics, Wiley, 2016, ⟨10.1111/apt.13770⟩
BASE-Bielefeld Academic Search Engine
Alimentary Pharmacology & Therapeutics
Munteanu, M.; Tiniakos, D.; Anstee, Q.; Charlotte, F.; Marchesini, G.; Bugianesi, E.; Trauner, M.; Romero Gomez, M.; Oliveira, C.; Day, C.; Dufour, Jean-François; Bellentani, S.; Ngo, Y.; Traussnig, S.; Perazzo, H.; Deckmyn, O.; Bedossa, P.; Ratziu, V.; Poynard, T. (2016). Diagnostic performance of FibroTest, SteatoTest and ActiTest in patients with NAFLD using the SAF score as histological reference. Alimentary pharmacology & therapeutics, 44(8), pp. 877-889. Wiley-Blackwell 10.1111/apt.13770 <http://dx.doi.org/10.1111/apt.13770Test>
Alimentary Pharmacology and Therapeutics, 2016, ⟨10.1111/apt.13770⟩
بيانات النشر: HAL CCSD, 2016.
سنة النشر: 2016
مصطلحات موضوعية: Liver Cirrhosis, Male, medicine.medical_specialty, Biopsy, 610 Medicine & health, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Fibrosis, Non-alcoholic Fatty Liver Disease, Internal medicine, medicine, Humans, Pharmacology (medical), Prospective Studies, Stage (cooking), Prospective cohort study, Grading (tumors), Inflammation, Hematologic Tests, Hepatology, medicine.diagnostic_test, business.industry, FibroTest, Fatty liver, Middle Aged, medicine.disease, 3. Good health, Non‐invasive Tests of Nafld, Fatty Liver, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Original Article, Female, Steatosis, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
الوصف: the FLIP Consortium and the FibroFrance Group; International audience; BackgroundBlood tests of liver injury are less well validated in non-alcoholic fatty liver disease (NAFLD) than in patients with chronic viral hepatitis.AimsTo improve the validation of three blood tests used in NAFLD patients, FibroTest for fibrosis staging, SteatoTest for steatosis grading and ActiTest for inflammation activity grading.MethodsWe pre-included new NAFLD patients with biopsy and blood tests from a single-centre cohort (FibroFrance) and from the multicentre FLIP consortium. Contemporaneous biopsies were blindly assessed using the new steatosis, activity and fibrosis (SAF) score, which provides a reliable and reproducible diagnosis and grading/staging of the three elementary features of NAFLD (steatosis, inflammatory activity) and fibrosis with reduced interobserver variability. We used nonbinary-ROC (NonBinAUROC) as the main endpoint to prevent spectrum effect and multiple testing.ResultsA total of 600 patients with reliable tests and biopsies were included. The mean NonBinAUROCs (95% CI) of tests were all significant (P < 0.0001): 0.878 (0.864–0.892) for FibroTest and fibrosis stages, 0.846 (0.830–0.862) for ActiTest and activity grades, and 0.822 (0.804–0.840) for SteatoTest and steatosis grades. FibroTest had a higher NonBinAUROC than BARD (0.836; 0.820–0.852; P = 0.0001), FIB4 (0.845; 0.829–0.861; P = 0.007) but not significantly different than the NAFLD score (0.866; 0.850–0.882; P = 0.26). FibroTest had a significant difference in median values between adjacent stage F2 and stage F1 contrarily to BARD, FIB4 and NAFLD scores (Bonferroni test P < 0.05).ConclusionsIn patients with NAFLD, SteatoTest, ActiTest and FibroTest are non-invasive tests that offer an alternative to biopsy, and they correlate with the simple grading/staging of the SAF scoring system across the three elementary features of NAFLD: steatosis, inflammatory activity and fibrosis.
وصف الملف: application/pdf; STAMPA
اللغة: English
تدمد: 0269-2813
1365-2036
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43eb2c8dc1d390f1abb8e94c48012738Test
https://hal.sorbonne-universite.fr/hal-01358160Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....43eb2c8dc1d390f1abb8e94c48012738
قاعدة البيانات: OpenAIRE
الوصف
تدمد:02692813
13652036