Integrated Analysis of the Clinical and Molecular Characteristics of IDH Wild-Type Gliomas in the Chinese Glioma Genome Atlas
| العنوان: | Integrated Analysis of the Clinical and Molecular Characteristics of IDH Wild-Type Gliomas in the Chinese Glioma Genome Atlas |
|---|---|
| المؤلفون: | Peng Wang, Yanwei Liu, Lin Zhi, Xiaoguang Qiu |
| المصدر: | Frontiers in Oncology, Vol 11 (2021) Frontiers in Oncology |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, IDH wild-type, whole exome sequencing, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Text mining, molecular pathology, Glioma, Internal medicine, Medicine, Exome sequencing, RC254-282, Original Research, business.industry, Molecular pathology, Wild type, Cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, Epileptic seizure, medicine.symptom, business, Lower-grade glioma, Glioblastoma |
| الوصف: | PurposeCurrent studies and guidelines suggest that the biobehavior of IDH-wild type (IDH-wt) lower-grade glioma (LGG, WHO II-III) is similar to IDH-wt glioblastoma (GBM). However, differences in their clinical and molecular characteristics have not been reported. This study aimed to analyze the clinical and genetic information of gliomas with IDH-wt.Methods389 patients with IDH-wt were enrolled in the study (LGG=165, GBM=224), and their clinical and genetic information was collected from the Chinese Glioma Genome Atlas (CGGA). We conducted an analysis of this information between the two groups of patients and drew conclusions thereof.ResultsThe median age of the LGG patients was 42 (18–74) years, whereas that of the GBM patients was 51 (18–79) years (P < 0.010). GBM patients were more likely to undergo total resection (P = 0.018) and had fewer epileptic seizure symptoms (P < 0.001). The median overall survival (OS) was 55 months for the LGG patients and only 14.83 months for the GBM patients (P < 0.01). The median progression-free survival (PFS) was 44 months for the LGG patients and only 9.767 months for the GBM patients (P < 0.001). GBM patients were more prone to PETN mutations (P = 0.010). Transcriptome analysis showed that the differentially expressed genes in LGG patients were mainly enriched in metabolic pathways and pathways in cancer and in the function of signal transduction and positive regulation of GTPase activity, whereas in GBM patients, they were mainly enriched in the PI3K-Akt signaling pathway and in the functions of apoptotic process and oxidation-reduction process.ConclusionsOur data indicate that these two groups of patients should be re-evaluated and treated differently, despite both having IDH wild type. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e24446ec7b9f2f5c435e457ee019daTest https://www.frontiersin.org/articles/10.3389/fonc.2021.696214/fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....43e24446ec7b9f2f5c435e457ee019da |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |