The elevation of plasma concentrations of apoB-48-containing lipoproteins in familial hypercholesterolemia is independent of PCSK9 levels
| العنوان: | The elevation of plasma concentrations of apoB-48-containing lipoproteins in familial hypercholesterolemia is independent of PCSK9 levels |
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| المؤلفون: | Jean-Philippe Drouin-Chartier, Jean-Charles Hogue, Patrick Couture, Jean Bergeron, André J. Tremblay, Benoît Lamarche |
| المصدر: | Lipids in Health and Disease Lipids in Health and Disease, Vol 16, Iss 1, Pp 1-8 (2017) |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Apolipoprotein B-48, Adult, Male, medicine.medical_specialty, Apolipoprotein B, Adolescent, Clinical chemistry, Endocrinology, Diabetes and Metabolism, Lipoproteins, Clinical Biochemistry, Familial hypercholesterolemia, Clinical nutrition, Hyperlipoproteinemia Type II, PCSK9, 03 medical and health sciences, Young Adult, Endocrinology, Internal medicine, medicine, Humans, Point Mutation, Child, lcsh:RC620-627, biology, business.industry, Research, Biochemistry (medical), Middle Aged, medicine.disease, Atherosclerosis, lcsh:Nutritional diseases. Deficiency diseases, 030104 developmental biology, LDL receptor, Apolipoprotein B-100, biology.protein, lipids (amino acids, peptides, and proteins), Female, Proprotein Convertase 9, business, Lipidology |
| الوصف: | Previous studies have reported high plasma concentrations of both intestinal apolipoprotein (apo) B-48-containing lipoproteins and PCSK9 in subjects with familial hypercholesterolemia (FH). However, the extent to which LDL receptor deficiency and PCSK9 levels influence plasma apoB-48 concentrations in humans remains to be fully characterized. The objective of the study was to assess the independent association between FH, PCSK9 concentrations and plasma apoB-48 levels in a large cohort of genetically defined FH heterozygotes (HeFH) and homozygotes (HoFH). A total of 118 HeFH, 6 HoFH, and 117 controls were included in the study. Plasma PCSK9 and apoB-48 concentrations were measured in the fasting state. Plasma PCSK9 and apoB-48 levels were higher in FH subjects compared with controls (PCSK9: HoFH: 642.6 ± 246.9 vs. HeFH: 324.9 ± 119.8 vs. controls: 194.5 ± 65.9 ng/mL, P |
| تدمد: | 1476-511X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ea963de7cc2943e6a5f125c2ea3fedTest https://pubmed.ncbi.nlm.nih.gov/28619117Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....42ea963de7cc2943e6a5f125c2ea3fed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1476511X |
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