Activity of trovafloxacin against blood isolates ofStreptococcus pneumoniae in Sweden
| العنوان: | Activity of trovafloxacin against blood isolates ofStreptococcus pneumoniae in Sweden |
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| المؤلفون: | B. M. Hoffman, J. Hedlund, B. Olsson-Liljequist |
| المصدر: | European Journal of Clinical Microbiology & Infectious Diseases. 15:671-675 |
| بيانات النشر: | Springer Science and Business Media LLC, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Microbiology (medical), Bacteremia, Microbial Sensitivity Tests, Biology, medicine.disease_cause, Microbiology, Anti-Infective Agents, Streptococcus pneumoniae, medicine, Humans, Naphthyridines, Sulfamethoxazole, Drug Resistance, Microbial, General Medicine, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, medicine.disease, Trimethoprim, Ciprofloxacin, Penicillin, Trovafloxacin, Pneumococcal infections, Infectious Diseases, Ofloxacin, Fluoroquinolones, medicine.drug |
| الوصف: | The in vitro activity of the fluoroquinolone trovafloxacin (CP-99,219) against 257 blood isolates of Streptococcus pneumoniae obtained from Swedish hospitals was compared with those of commonly prescribed oral antibiotics and also with those of ciprofloxacin and ofloxacin against a collection of strains resistant (n = 6) or intermediately resistant (n = 22) to penicillin (Pc-R). The MICs of trovafloxacin for Pc-R strains of pneumococci ranged from 0.032 to 0.25 mg/l. No difference was seen between the clinical isolates and the Pc-R strains (MIC50 = 0.064 mg/l and MIC90 = 0.125 mg/l for both collections). For the Pc-R strains, the MIC50 and MIC90 values of ciprofloxacin were 0.5 and 1 mg/l, and those of ofloxacin 2 and 4 mg/l. The incidence of resistance in the two collections (clinical isolates/Pc-R strains) was 3%/39% for tetracycline, 1%/18% for macrolides, and 3%/57% for trimethoprim/sulfamethoxazole. The results of the current study suggest that the clinical efficacy of trovafloxacin in the treatment of pneumococcal infections should be investigated. |
| تدمد: | 1435-4373 0934-9723 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e769a4e779774ddd2a7e4b86e44020Test https://doi.org/10.1007/bf01691157Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....42e769a4e779774ddd2a7e4b86e44020 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14354373 09349723 |
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