A prospective case-control study on miRNA circulating levels in subjects born small for gestational age (SGA) evaluated from childhood into young adulthood
| العنوان: | A prospective case-control study on miRNA circulating levels in subjects born small for gestational age (SGA) evaluated from childhood into young adulthood |
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| المؤلفون: | Mireille Vanpée, Anna Kistner, Stefano Cianfarani, Annalisa Deodati, Katarina Berinder, Elena Inzaghi, Lena Legnevall, Daniela Germani |
| المصدر: | PLoS ONE PLoS ONE, Vol 15, Iss 1, p e0228075 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Leptin, 0301 basic medicine, Male, Glycated Hemoglobin A, Physiology, Peptide Hormones, medicine.medical_treatment, Type 2 diabetes, Biochemistry, Fats, Endocrinology, 0302 clinical medicine, Immune Physiology, Medicine and Health Sciences, Insulin, Medicine, Prospective Studies, Young adult, Prospective cohort study, Child, reproductive and urinary physiology, Innate Immune System, Multidisciplinary, Lipids, Settore MED/38, female genital diseases and pregnancy complications, Nucleic acids, Physiological Parameters, Infant, Small for Gestational Age, Cytokines, Regression Analysis, Female, Adiponectin, Research Article, Childhood Obesity, Adolescent, Science, Immunology, 030209 endocrinology & metabolism, 03 medical and health sciences, Young Adult, Insulin resistance, Adipokines, Genetics, Adults, Humans, Obesity, Circulating MicroRNA, Non-coding RNA, Glycated Hemoglobin, Diabetic Endocrinology, Natural antisense transcripts, Biology and life sciences, Endocrine Physiology, business.industry, Body Weight, Case-control study, Infant, Molecular Development, medicine.disease, Hormones, Gene regulation, MicroRNAs, 030104 developmental biology, Gene Expression Regulation, Age Groups, Immune System, Case-Control Studies, People and Places, RNA, Small for gestational age, Small for Gestational Age, Population Groupings, Gene expression, Insulin Resistance, business, Developmental Biology |
| الوصف: | Objective microRNAs (miRNAs) associated with metabolic risk have never been extensively investigated in SGA subjects. The aim of the current study was to evaluate miRNAs in SGA and AGA subjects and their relationships with the metabolic status and growth. Design and methods A prospective longitudinal case-control study was performed in 23 SGA with postnatal catch-up growth and 27 AGA subjects evaluated at the age of 9 and 21 years. Circulating levels of miR-122-5p, miR-16-5p, miR-126-3p, and miR-486-5p were assessed by qPCR. Results SGA subjects were shorter both at 9 and at 21 years. No significant differences in insulin like growth factors and metabolic profile were found with the exception of basal glycemia at 9 years. miRNA levels did not differ between SGA and AGA subjects, at 9 and 21 years. miR-16-5p and miR-126-3p levels were higher at 9 than at 21 years. In SGA subjects, miR-122-5p at 9 years was inversely related to adiponectin levels at 21 years and miR-486-5p at 9 years was inversely related to whole-body insulin sensitivity at 9 years and directly related to Hb1Ac at 21 years. Regression analyses showed no predictive value of miRNAs for growth parameters in neither SGA nor AGA subjects. Conclusions SGA with postnatal catch-up growth did not show any difference in metabolic risk markers or miRNA circulating levels compared to AGA controls in childhood and young adulthood. miR-122-5p during childhood could identify SGA subjects at higher risk of developing insulin resistance and, eventually, type 2 diabetes in adulthood but further studies are needed to confirm it. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422e00791c5368082dfc51e61f2201c9Test http://hdl.handle.net/2108/263675Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....422e00791c5368082dfc51e61f2201c9 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |