Effects of running wheel training on adult obese rats programmed by maternal prolactin inhibition
| العنوان: | Effects of running wheel training on adult obese rats programmed by maternal prolactin inhibition |
|---|---|
| المؤلفون: | Gabriel Boaventura, Gustavo Casimiro-Lopes, Egberto Gaspar de Moura, C. C. Pazos-Moura, Patricia Cristina Lisboa, Elaine de Oliveira |
| المصدر: | Journal of Endocrinology. 219:29-37 |
| بيانات النشر: | Bioscientifica, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Offspring, Endocrinology, Diabetes and Metabolism, Mothers, Weaning, Motor Activity, chemistry.chemical_compound, Endocrinology, Physical Conditioning, Animal, Internal medicine, Lactation, medicine, Animals, Obesity, Rats, Wistar, Bromocriptine, Metabolic Syndrome, L-Lactate Dehydrogenase, medicine.diagnostic_test, Glycogen, business.industry, Muscles, Lipid Metabolism, medicine.disease, Prolactin, Rats, medicine.anatomical_structure, chemistry, Female, medicine.symptom, Metabolic syndrome, Lipid profile, business, Weight gain, medicine.drug |
| الوصف: | The inhibition of maternal prolactin production in late lactation leads to metabolic syndrome and hypothyroidism in adult offspring. Physical training is a therapeutic strategy that could prevent or reverse this condition. We evaluated the effects of a short-duration low-intensity running wheel training program on the metabolic and hormonal alterations in rats. Lactating Wistar rats were treated with bromocriptine (Bro, 1 mg twice a day) or saline on days 19, 20, and 21 of lactation, and the training of offspring began at 35 days of age. Offspring were divided into sedentary and trained controls (C-Sed and C-Ex) and sedentary and trained Bro-treated rats (Bro-Sed and Bro-Ex). Chronic exercise delayed the onset of weight gain in Bro-Ex offspring, and the food intake did not change during the experimental period. At 180 days, visceral fat mass was higher (+46%) in the Bro-Sed offspring than in C-Sed and Bro-Ex rats. As expected, running capacity was higher in trained animals. Most parameters observed in the Bro-Sed offspring were consistent with hypothyroidism and metabolic syndrome and were reversed in the Bro-Ex group. Chronic exercise did not influence the muscle glycogen in the C-Ex group; however, liver glycogen was higher (+30%) in C-Ex group and was unchanged in both Bro offspring groups. Bro-Ex animals had higher plasma lactate dehydrogenase levels, indicating skeletal muscle damage and intolerance of the training program. Low-intensity chronic training is able to normalize many clinical aspects in Bro animals; however, these animals might have had a lower threshold for exercise adaptation than the control rats. |
| تدمد: | 1479-6805 0022-0795 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b6a348637de46e6b828752d5787d53Test https://doi.org/10.1530/joe-13-0102Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....41b6a348637de46e6b828752d5787d53 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14796805 00220795 |
|---|