Magnitude of elevated iron stores and risk associated in steady state sickle cell anemia Congolese children: a cross sectional study
| العنوان: | Magnitude of elevated iron stores and risk associated in steady state sickle cell anemia Congolese children: a cross sectional study |
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| المؤلفون: | Rosette Kevani Lepira, François B. Lepira, Gloire Mavinga Bundutidi, Jean Lambert Gini, Jean-Robert Makulo, René Makuala Ngiyulu, Karen Efombola Itokua, Michel Ntetani Aloni |
| المصدر: | BMC Hematology BMC Hematology, Vol 19, Iss 1, Pp 1-6 (2019) |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | medicine.medical_specialty, Univariate analysis, Hematology, Blood transfusion, Cross-sectional study, business.industry, lcsh:RC633-647.5, medicine.medical_treatment, lcsh:Diseases of the blood and blood-forming organs, Elevated iron stores, medicine.disease, Gastroenterology, Sickle cell anemia, Polytransfusions, Internal medicine, medicine, Steady state (chemistry), Risk factor, business, Molecular Biology, DR Congo, Angiology, Research Article |
| الوصف: | Background The serum ferritin assay is recommended in Sickle Cell Anemia (SCA) patients receiving regular transfusions. According to several authors, elevated iron stores indicating iron chelation corresponds to hyperferritinemia ≥500 ng/ml, and becomes detectable after twenty blood transfusions. The objectives of the study were to determine the prevalence of elevated iron stores and identify associated risk factors in a case series of Steady state SCA Congolese children. Material and methods Serum ferritin was assayed in Steady state SCA children followed in 2 specialized hospitals in Kinshasa. Elevated iron stores was defined as serum ferritin level ≥ 500 ng/ml, and the associated risk factors were identified using univariate analysis. Results Seventy patients (median age 9 years, 56% boys, 53% receiving hydroxyurea) were selected in the study. Serum ferritin levels ranged from 24 to 2584 ng / ml with 21.4% of children having elevated iron stores. Mean levels of LDH, indirect bilirubin, plasma free Hb and CRP were similar between the 2 groups whereas history of polytransfusions (> 3 during the last year) was more frequent among patients with elevated iron stores (73% vs. 44%, p = 0.078). Receiving > 3 transfusions in a year vs. 0 was the main risk factor associated with elevated iron stores [OR 6.17 (95% CI: 1.81–20.96)]. Conclusion In SCA children, hyperferritinemia requiring iron chelation is most strongly related to blood transfusion. This situation concerned almost one in five children in present study; this shows the magnitude of the problem which is underestimated. |
| تدمد: | 2052-1839 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408954382d3153e2b33430584211dff9Test https://pubmed.ncbi.nlm.nih.gov/30774961Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....408954382d3153e2b33430584211dff9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20521839 |
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