Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan
| العنوان: | Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan |
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| المؤلفون: | Yukiyoshi Moriuchi, Yasuko Sagara, Toshiki Watanabe, Yoshio Saburi, Masao Ogata, Manabu Mochizuki, Shimeru Kamihira, Kazunari Yamaguchi, Junji Tanaka, Ki-Ryang Koh, Shigeo Hino, Kaoru Uchimaru, Akihiko Okayama, Masako Iwanaga, Atae Utsunomiya, Kimiharu Uozumi, Kunihiro Tsukasaki, Masaomi Yamamura, Hiroshi Kikuchi |
| المصدر: | Blood. 116:1211-1219 |
| بيانات النشر: | American Society of Hematology, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, viruses, Immunology, Biochemistry, Asymptomatic, Young Adult, Japan, Proviruses, immune system diseases, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Leukemia-Lymphoma, Adult T-Cell, Prospective Studies, Family history, Child, Prospective cohort study, Aged, Aged, 80 and over, Human T-lymphotropic virus 1, Hematology, biology, business.industry, Cell Biology, Middle Aged, Viral Load, Prognosis, biology.organism_classification, medicine.disease, HTLV-I Infections, Deltaretrovirus, Blotting, Southern, Leukemia, Carrier State, DNA, Viral, Disease Progression, Female, medicine.symptom, business, Viral load, Biomarkers, Follow-Up Studies |
| الوصف: | Definitive risk factors for the development of adult T-cell leukemia (ATL) among asymptomatic human T-cell leukemia virus type I (HTLV-1) carriers remain unclear. Recently, HTLV-1 proviral loads have been evaluated as important predictors of ATL, but a few small prospective studies have been conducted. We prospectively evaluated 1218 asymptomatic HTLV-1 carriers (426 males and 792 females) who were enrolled during 2002 to 2008. The proviral load at enrollment was significantly higher in males than females (median, 2.10 vs 1.39 copies/100 peripheral blood mononuclear cells [PBMCs]; P < .001), in those 40 to 49 and 50 to 59 years of age than that of those 40 years of age and younger (P = .02 and .007, respectively), and in those with a family history of ATL than those without the history (median, 2.32 vs 1.33 copies/100 PBMCs; P = .005). During follow-up, 14 participants progressed to overt ATL. Their baseline proviral load was high (range, 4.17-28.58 copies/100 PBMCs). None developed ATL among those with a baseline proviral load lower than approximately 4 copies. Multivariate Cox analyses indicated that not only a higher proviral load, advanced age, family history of ATL, and first opportunity for HTLV-1 testing during treatment for other diseases were independent risk factors for progression of ATL. |
| تدمد: | 1528-0020 0006-4971 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403cc01c2b51600419e2a889fb41b873Test https://doi.org/10.1182/blood-2009-12-257410Test |
| رقم الانضمام: | edsair.doi.dedup.....403cc01c2b51600419e2a889fb41b873 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280020 00064971 |
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