Short-term use of adaptive servo ventilation improves renal function in heart failure patients with sleep-disordered breathing
| العنوان: | Short-term use of adaptive servo ventilation improves renal function in heart failure patients with sleep-disordered breathing |
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| المؤلفون: | Makiko Miyata, Hitoshi Suzuki, Takashi Owada, Hiroyuki Kunii, Shu-ichi Saitoh, Satoshi Suzuki, Akiomi Yoshihisa, Kazuhiko Nakazato, Shoji Iwaya, Takayoshi Yamaki, Hiroyuki Yamauchi, Yasuchika Takeishi, Koichi Sugimoto |
| المصدر: | Heart and Vessels. 28:728-734 |
| بيانات النشر: | Springer Science and Business Media LLC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Time Factors, Central sleep apnea, Polysomnography, Renal function, Kidney, urologic and male genital diseases, Ventricular Function, Left, chemistry.chemical_compound, Sleep Apnea Syndromes, Internal medicine, Natriuretic Peptide, Brain, medicine, Humans, cardiovascular diseases, Cheyne-Stokes Respiration, Cystatin C, Aged, Heart Failure, Creatinine, Ejection fraction, medicine.diagnostic_test, biology, business.industry, Stroke Volume, Middle Aged, medicine.disease, Respiration, Artificial, Peptide Fragments, respiratory tract diseases, Treatment Outcome, Endocrinology, Apnea–hypopnea index, chemistry, Heart failure, Chronic Disease, Cardiology, biology.protein, Female, Cardiology and Cardiovascular Medicine, business, Biomarkers, Glomerular Filtration Rate |
| الوصف: | Sleep-disordered breathing (SDB) deteriorates the prognosis of patients with chronic heart failure (CHF). Adaptive servo ventilation (ASV) is a new therapeutic modality to treat SDB including Cheyne-Stokes respiration associated with central sleep apnea. Renal function plays critical roles in the progression of CHF and is a strong predictor of clinical outcomes. Cystatin C is a marker of renal function, and more sensitive than serum creatinine. The purpose of the present study was to examine whether ASV is effective for cardiac overload and renal dysfunction in CHF patients with SDB. Fifty patients with CHF and SDB (mean left ventricular ejection fraction 34.0 %, estimated glomerular filtration rate (eGFR) 62.8 ml/min/1.73 cm(2)) were examined. We performed polysomnography for two consecutive days (baseline and on ASV), and measured levels of serum N terminal-pro B-type natriuretic peptide (NT-pro BNP), cystatin C, and estimated glomerular filtration rate based on cystatin C (eGFR Cyst C). ASV significantly improved the apnea hypopnea index, central apnea index, obstructive apnea index, arousal index, mean SPO2, and lowest SPO2 compared to baseline. ASV decreased NT-pro BNP (1,109.0 (2,173.2) to 912.8 (1,576.7) pg/ml, p 0.05), cystatin C (1.391 ± 0.550-1.348 ± 0.489 mg/l, p 0.05), and increased eGFR Cyst C (61.9 ± 30.8-65.7 ± 33.8 ml/min/1.73 cm(2), p 0.01). ASV improved SDB, reduced cardiac overload, and ameliorated renal function in CHF patients with SDB. ASV has short-term beneficial effects on not only SDB but also cardio-renal function. ASV might be a promising useful tool for CHF as an important non-pharmacotherapy with cardio-renal protection. |
| تدمد: | 1615-2573 0910-8327 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40199b1593604d09f1859e38295ad939Test https://doi.org/10.1007/s00380-012-0303-0Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....40199b1593604d09f1859e38295ad939 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16152573 09108327 |
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