Endothelium-Specific Deficiency of Polycystin-1 Promotes Hypertension and Cardiovascular Disorders
| العنوان: | Endothelium-Specific Deficiency of Polycystin-1 Promotes Hypertension and Cardiovascular Disorders |
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| المؤلفون: | Mouad Hamzaoui, Deborah Groussard, Dorian Nezam, Zoubir Djerada, Gaspard Lamy, Virginie Tardif, Anais Dumesnil, Sylvanie Renet, Valery Brunel, Dorien J.M. Peters, Laurence Chevalier, Mélanie Hanoy, Paul Mulder, Vincent Richard, Jeremy Bellien, Dominique Guerrot |
| المصدر: | Hypertension, 79(11), 2542-2551. LIPPINCOTT WILLIAMS & WILKINS |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | TRPP Cation Channels, hypertension, autosomal dominant polycystic kidney disease, Endothelial Cells, Polycystic Kidney, Autosomal Dominant, Mechanotransduction, Cellular, endothelial dysfunction, Mice, Cardiovascular Diseases, Arteriovenous Fistula, Internal Medicine, Humans, Animals, polycystin, ciliopathies, Endothelium, Renal Insufficiency, Chronic, chronic kidney disease |
| الوصف: | Background: Autosomal dominant polycystic kidney disease is the most frequent hereditary kidney disease and is generally due to mutations in PKD1 and PKD2 , encoding polycystins 1 and 2. In autosomal dominant polycystic kidney disease, hypertension and cardiovascular disorders are highly prevalent, but their mechanisms are partially understood. Methods: Since endothelial cells express the polycystin complex, where it plays a central role in the mechanotransduction of blood flow, we generated a murine model with inducible deletion of Pkd1 in endothelial cells ( Cdh5-Cre ERT2 ; Pkd1 fl/fl ) to specifically determine the role of endothelial polycystin-1 in autosomal dominant polycystic kidney disease. Results: Endothelial deletion of Pkd1 induced endothelial dysfunction, as demonstrated by impaired flow-mediated dilatation of resistance arteries and impaired relaxation to acetylcholine, increased blood pressure and prevented the normal development of arteriovenous fistula. In experimental chronic kidney disease induced by subtotal nephrectomy, endothelial deletion of Pkd1 further aggravated endothelial dysfunction, vascular remodeling, and heart hypertrophy. Conclusions: Altogether, this study provides the first in vivo demonstration that specific deletion of Pkd1 in endothelial cells promotes endothelial dysfunction and hypertension, impairs arteriovenous fistula development, and potentiates the cardiovascular alterations associated with chronic kidney disease. |
| وصف الملف: | application/pdf |
| تدمد: | 1524-4563 0194-911X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7b6358e1e2b02bd647c132f2a042beTest https://doi.org/10.1161/hypertensionaha.122.19057Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3f7b6358e1e2b02bd647c132f2a042be |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244563 0194911X |
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