A 12-month weight loss intervention in adults with obstructive sleep apnoea: is timing important? A step wedge randomised trial
| العنوان: | A 12-month weight loss intervention in adults with obstructive sleep apnoea: is timing important? A step wedge randomised trial |
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| المؤلفون: | Helen Truby, Bradley A. Edwards, Kaitlin Day, Denise M. O’Driscoll, Alan Young, Ladan Ghazi, Claire Bristow, Kerryn Roem, Maxine P. Bonham, Chiara Murgia, Terry P. Haines, Garun S. Hamilton |
| المصدر: | European Journal of Clinical Nutrition. 76:1762-1769 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Adult, Male, Sleep Apnea, Obstructive, Nutrition and Dietetics, Continuous Positive Airway Pressure, Weight Loss, Humans, Medicine (miscellaneous), Female, Obesity, Middle Aged, Life Style |
| الوصف: | Background/Objectives Continuous positive airway pressure (CPAP) concomitant with weight loss is a recommended treatment approach for adults with moderate-severe obstructive sleep apnoea (OSA) and obesity. This requires multiple synchronous behaviour changes. The aim of this study was to examine the effectiveness of a 6-month lifestyle intervention and to determine whether the timing of starting a weight loss attempt affects weight change and trajectory after 12 months in adults newly diagnosed with moderate-severe OSA and treated at home with overnight CPAP. Methods Using a stepped-wedge design, participants were randomised to commence a six-month lifestyle intervention between one and six-months post-enrolment, with a 12-month overall follow-up. Adults (n = 60, 75% males, mean age 49.4 SD 10.74 years) newly diagnosed with moderate-severe OSA and above a healthy weight (mean BMI 34.1 SD 4.8) were recruited. Results After 12 months, exposure to the intervention (CPAP and lifestyle) resulted in a 3.7 (95% CI: 2.6 to 4.8, p p = 0.86). Conclusions The lifestyle intervention resulted in a modest reduction in body weight, while timing of commencement did not impact the degree of weight loss at 12 months. These findings support the recommendation of adjunctive weight-loss interventions within six-months of starting CPAP. |
| تدمد: | 1476-5640 0954-3007 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7ae12c756a9cb3e20cebb08f0ec938Test https://doi.org/10.1038/s41430-022-01184-5Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3f7ae12c756a9cb3e20cebb08f0ec938 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765640 09543007 |
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