High plasma level of asymmetric dimethylarginine in patients with acutely exacerbated congestive heart failure: role in reduction of plasma nitric oxide level
| العنوان: | High plasma level of asymmetric dimethylarginine in patients with acutely exacerbated congestive heart failure: role in reduction of plasma nitric oxide level |
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| المؤلفون: | Toshiro Matsunaga, Tomohiro Osanai, Masayuki Saitoh, Ken Okumura, Takaatsu Kamada, Hiroyuki Hanada, Hiroshi Ishizaka |
| المصدر: | Heart and Vessels. 18:177-182 |
| بيانات النشر: | Springer Science and Business Media LLC, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Exacerbation, Arginine, Nitric Oxide, Nitric oxide, chemistry.chemical_compound, Internal medicine, medicine, Humans, cardiovascular diseases, Enzyme Inhibitors, Nitrite, Chromatography, High Pressure Liquid, health care economics and organizations, Heart Failure, biology, Tumor Necrosis Factor-alpha, business.industry, Middle Aged, medicine.disease, Cardiac surgery, Nitric oxide synthase, Endocrinology, chemistry, Heart failure, Acute Disease, Chronic Disease, cardiovascular system, biology.protein, Cytokines, Female, Tumor necrosis factor alpha, Nitric Oxide Synthase, Cardiology and Cardiovascular Medicine, business, Asymmetric dimethylarginine, human activities, circulatory and respiratory physiology |
| الوصف: | Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, is elevated in congestive heart failure (CHF) concomitantly with the higher levels of nitric oxide (NO) and cytokines. We investigated the association among ADMA, NO, and cytokines in human CHF. Blood was collected from 25 patients with acutely exacerbated chronic CHF (acute CHF, mean age 61 +/- 3 years), 23 patients with chronic compensated CHF (chronic CHF, mean age 62 +/- 2 years), and 26 control subjects (mean age 51 +/- 1 years). ADMA was measured by high-performance liquid chromatography. Tumor necrosis factor-alpha (TNF-alpha) was measured by enzyme-linked immunosorbent assay. Nitrate plus nitrite (NOx) was measured by the Griess method. The plasma levels of ADMA and TNF-Alpha were higher in patients with acute CHF than in those with chronic CHF and control subjects (both P0.05). The plasma level of NOx was higher in patients with chronic CHF than in those with acute CHF and control subjects (both P0.01). The plasma level of TNF-Alpha was positively correlated with that of ADMA in combination with patients with acute and chronic CHF (r = 0.31, P0.01). The plasma level of ADMA was, furthermore, negatively correlated with that of NOx (r = -0.29, P0.05). These findings indicate that ADMA is related to exacerbation of chronic CHF by suppression of the compensatory higher level of plasma NO. |
| تدمد: | 1615-2573 0910-8327 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3691a683f765f43642d5dfd20ec71aTest https://doi.org/10.1007/s00380-003-0715-yTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....3f3691a683f765f43642d5dfd20ec71a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16152573 09108327 |
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