Non‐canonical functions of the tuberous sclerosis complex‐Rheb signalling axis
| العنوان: | Non‐canonical functions of the tuberous sclerosis complex‐Rheb signalling axis |
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| المؤلفون: | Elizabeth P. Henske, Nicole A. Neuman |
| المصدر: | EMBO Molecular Medicine |
| بيانات النشر: | EMBO, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | congenital, hereditary, and neonatal diseases and abnormalities, Rheb, lymphangioleiomyomatosis, tuberous sclerosis complex, Tuberous Sclerosis Complex 1 Protein, Tuberous sclerosis, Tuberous Sclerosis, non-canonical, Tuberous Sclerosis Complex 2 Protein, medicine, Animals, Humans, In Focus, PI3K/AKT/mTOR pathway, Monomeric GTP-Binding Proteins, biology, TOR Serine-Threonine Kinases, Tumor Suppressor Proteins, Neuropeptides, medicine.disease, nervous system diseases, Tuberous sclerosis protein, medicine.anatomical_structure, Biochemistry, Lymphangioleiomyomatosis, mTOR, biology.protein, Molecular Medicine, Ras Homolog Enriched in Brain Protein, TSC1, TSC2, Neuroscience, Signal Transduction, RHEB |
| الوصف: | The protein products of the tuberous sclerosis complex (TSC) genes, TSC1 and TSC2, form a complex, which inhibits the small G-protein, Ras homolog enriched in brain (Rheb). The vast majority of research regarding these proteins has focused on mammalian Target of Rapamycin (mTOR), a target of Rheb. Here, we propose that there are clinically relevant functions and targets of TSC1, TSC2 and Rheb, which are independent of mTOR. We present evidence that such non-canonical functions of the TSC-Rheb signalling network exist, propose a standard of evidence for these non-canonical functions, and discuss their potential clinical and therapeutic implications for patients with TSC and lymphangioleiomyomatosis (LAM). |
| تدمد: | 1757-4684 1757-4676 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0448639bd3ca7ae226b3c9d179c653Test https://doi.org/10.1002/emmm.201100131Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3e0448639bd3ca7ae226b3c9d179c653 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17574684 17574676 |
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