3′ untranslated region A>C (rs3212227) polymorphism of Interleukin 12B gene as a potential risk factor for Hodgkin’s lymphoma in Brazilian children and adolescents
| العنوان: | 3′ untranslated region A>C (rs3212227) polymorphism of Interleukin 12B gene as a potential risk factor for Hodgkin’s lymphoma in Brazilian children and adolescents |
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| المؤلفون: | Rocio Hassan, Edileine Dellalibera, Adriana Morais, Ferreira Thiago de Barros, Nunes Amanda A Correia, Maria Tereza Cartaxo Muniz, de Oliveira Bárbara Silva, Maria do Socorro de Mendonça Cavalcanti, Luísa Priscilla Oliveira de Lima |
| المصدر: | Tumor Biology, Vol 41 (2019) |
| بيانات النشر: | IOS Press, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Adolescent, Genotype, Biology, Polymorphism, Single Nucleotide, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Immune system, Risk Factors, hemic and lymphatic diseases, medicine, Humans, Child, 3' Untranslated Regions, Gene, Alleles, RC254-282, Interleukin-12 Subunit p40, Potential risk, Three prime untranslated region, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Interleukin, General Medicine, Hodgkin's lymphoma, medicine.disease, Hodgkin Disease, Cross-Sectional Studies, 030104 developmental biology, T helper 1, Case-Control Studies, Child, Preschool, 030220 oncology & carcinogenesis, Immunology, Interleukin 12, Female, Brazil |
| الوصف: | Interleukin 12 plays an important role in immunoregulation between the T helper 1/T helper 2 lymphocytes and in the antiviral and antitumor immune response. The aim of this study was to investigate the possible association between the interleukin 12B polymorphism rs3212227 and the risk to develop Hodgkin’s lymphoma in childhood and adolescents. A total of 100 patients with Hodgkin’s lymphoma and a group of 181 healthy controls were selected at random from a forensic laboratory of the University of Pernambuco. The AA genotype was detected in the controls (53.04%) and the AC genotype was found in the patients (54%). The AC genotype showed an association with the development of Hodgkin’s lymphoma (odds ratio = 2.091, 95% confidence interval = 1.240–3.523, p = 0.007). When AC + CC genotypes were analyzed together, an increase in risk of 1.9 times more chances for HL development could be observed (odds ratio = 1.923, 95% confidence interval = 1.166–3.170, p = 0.014). However, there was no association between the AC and CC genotypes of the interleukin 12B polymorphism with the clinical risk group (p = 0.992, p = 0.648, respectively). Our results suggest that the presence of the C allele may be contributing to the development of Hodgkin’s lymphoma in children and adolescents. |
| تدمد: | 1423-0380 1010-4283 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d99dc787464288120c4c31c17a2a792Test https://doi.org/10.1177/1010428319860400Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3d99dc787464288120c4c31c17a2a792 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230380 10104283 |
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