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Interleukin-6 increases the expression of key proteins associated with steroidogenesis in human NCI-H295R adrenocortical cells

التفاصيل البيبلوغرافية
العنوان: Interleukin-6 increases the expression of key proteins associated with steroidogenesis in human NCI-H295R adrenocortical cells
المؤلفون: Allan M. Judd, James P. Porter, S. McIlmoil, Janae Strickland, Brice J. Williams, Dennis C. Seager
المصدر: Steroids. 119:1-17
بيانات النشر: Elsevier BV, 2017.
سنة النشر: 2017
مصطلحات موضوعية: 0301 basic medicine, Steroidogenic factor 1, medicine.medical_specialty, Hydrocortisone, Blotting, Western, Clinical Biochemistry, 030209 endocrinology & metabolism, Biology, Steroidogenic Factor 1, Biochemistry, Cell Line, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, medicine, Humans, RNA, Messenger, STAT1, Phosphorylation, STAT3, Molecular Biology, Janus Kinases, Pharmacology, Interleukin-6, Cholesterol side-chain cleavage enzyme, Steroidogenic acute regulatory protein, Organic Chemistry, JAK-STAT signaling pathway, STAT Transcription Factors, 030104 developmental biology, Adrenal Cortex, STAT protein, biology.protein, Steroids, Transcription Factors
الوصف: Mechanisms of interleukin-6 (IL-6)-induced cortisol release (CR) were investigated by exposing H295R cells to IL-6 and determining mRNA/protein expression (PCR/western blots) for steroidogenic enzymes (SE), steroidogenic acute regulatory protein (StAR), steroidogenic factor-1 (SF-1) (enhances SE/StAR expression), activator protein 1 (AP-1) (regulates SE/StAR expression) and adrenal hypoplasia congenita-like protein (DAX-1) (inhibits SE/StAR expression). Promoter activity of StAR (SPA) was measured by a luciferase-coupled promoter. Cortisol release was increased by 10ng/mL IL-6 (24h P
تدمد: 0039-128X
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf9e10694d5414095c33e1fdbda0f6bTest
https://doi.org/10.1016/j.steroids.2016.12.014Test
حقوق: CLOSED
رقم الانضمام: edsair.doi.dedup.....3cf9e10694d5414095c33e1fdbda0f6b
قاعدة البيانات: OpenAIRE
الوصف
تدمد:0039128X