Risk and tropism of central nervous system ( CNS ) metastases in patients with stage II and III cutaneous melanoma
| العنوان: | Risk and tropism of central nervous system ( |
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| المؤلفون: | Paul Johannet, Morgan Simons, Yingzhi Qian, Nadine Azmy, Janice M. Mehnert, Jeffrey S. Weber, Judy Zhong, Iman Osman |
| المصدر: | Cancer. 128:3620-3629 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Central Nervous System, Central Nervous System Neoplasms, Male, Cancer Research, Skin Neoplasms, Testicular Neoplasms, Oncology, Brain Neoplasms, Humans, Neoplasms, Second Primary, Melanoma, Tropism, Neoplasm Staging |
| الوصف: | Recent data suggest that patients with stage III melanoma are at high risk for developing central nervous system (CNS) metastases. Because a subset of patients with stage II melanoma experiences worse survival outcomes than some patients with stage III disease, the authors investigated the risk of CNS metastasis in stage II melanoma to inform surveillance guidelines for this population.The authors examined clinicopathologic data prospectively collected from 1054 patients who had cutaneous melanoma. The χPatients with stage III melanoma had a higher rate of developing brain metastases than those with stage II melanoma (100 of 468 patients [21.4%] vs. 82 of 586 patients [14.0%], respectively; p = .002). However, patients who had stage IIC melanoma had a significantly higher rate of isolated first recurrences in the CNS compared with those who had stage III disease (12.1% vs. 3.6%; p = .002). The risk of ever developing brain metastases was similarly elevated for patients who had stage IIC disease (hazard ratio [HR], 3.16; 95% CI, 1.77-5.66), stage IIIB disease (HR, 2.83; 95% CI, 1.63-4.91), and stage IIIC disease (HR, 2.93; 95% CI, 1.81-4.74), and the risk was highest in patients who had stage IIID disease (HR, 8.59; 95% CI: 4.11-17.97).Patients with stage IIC melanoma are at elevated risk for first recurrence in the CNS. Surveillance strategies that incorporate serial neuroimaging should be considered for these individuals until more accurate predictive markers can be identified. |
| تدمد: | 1097-0142 0008-543X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c97d628f040f7e2265ffc26342eafa4Test https://doi.org/10.1002/cncr.34435Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3c97d628f040f7e2265ffc26342eafa4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970142 0008543X |
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