Soluble Suppression Of Tumorigenicity-2 Predicts Hospital Mortality in Burn Patients: An Observational Prospective Cohort Pilot Study
| العنوان: | Soluble Suppression Of Tumorigenicity-2 Predicts Hospital Mortality in Burn Patients: An Observational Prospective Cohort Pilot Study |
|---|---|
| المؤلفون: | Mireia Ruiz-Castilla, Pau Bosacoma, Judith Marin-Corral, Joan R. Masclans, Oriol Roca, Juan P. Barret, Patricia Guilabert, Jacinto Baena, Bruce Dos Santos |
| المصدر: | Shock. 51:194-199 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Pilot Projects, Hospital mortality, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, Models, Biological, Disease-Free Survival, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Internal medicine, medicine, Humans, Hospital Mortality, Prospective Studies, Prospective cohort study, Aged, business.industry, 030208 emergency & critical care medicine, Plasma levels, Middle Aged, Interleukin-1 Receptor-Like 1 Protein, Survival Rate, Emergency Medicine, Female, Observational study, Burns, business, Biomarkers |
| الوصف: | The IL33/ST2 pathway has been implicated in the pathogenesis of different inflammatory diseases. Our aim was to analyze whether plasma levels of biomarkers involved in the IL33/ST2 axis might help to predict mortality in burn patients.Single-center prospective observational cohort pilot study performed at the Burns Unit of the Plastic and Reconstructive Surgery Department of the Vall d'Hebron University Hospital (Barcelona). All patients aged ≥18 years old with second or third-degree burns requiring admission to the Burns Unit were considered for inclusion. Blood samples were taken to measure levels of interleukins (IL)6, IL8, IL33, and soluble suppression of tumorigenicity-2 (sST2) within 24 h of admission to the Burns Unit and at day 3. Results are expressed as medians and interquartile ranges or as frequencies and percentages.Sixty-nine patients (58 [84.1%] male, mean age 52 [35-63] years, total body surface area burned 21% [13%-30%], Abbreviated Burn Severity Index 6 [4-8]) were included. Thirteen (18.8%) finally died in the Burns Unit. Plasma levels of sST2 measured at day 3 after admission demonstrated the best prediction accuracy for survival (area under the receiver-operating curve 0.85 [0.71-0.99]; P 0.001). The best cutoff point for the area under the receiver-operating curve index was estimated to be 2,561. In the Cox proportional hazards model, after adjusting for potential confounding, a plasma sST2 level ≥2,561 measured at day 3 was significantly associated with mortality (hazard ratio 6.94 [1.73-27.74]; P = 0.006).Plasma sST2 at day 3 predicts hospital mortality in burn patients. |
| تدمد: | 1540-0514 1073-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c726b264b58c9b6be88a4ea8e9bbabfTest https://doi.org/10.1097/shk.0000000000001155Test |
| رقم الانضمام: | edsair.doi.dedup.....3c726b264b58c9b6be88a4ea8e9bbabf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15400514 10732322 |
|---|