Expansion of pharmacist clinical services to optimize the management of immune checkpoint inhibitor toxicities
| العنوان: | Expansion of pharmacist clinical services to optimize the management of immune checkpoint inhibitor toxicities |
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| المؤلفون: | Ticiana A. Leal, Catherine E Renna, Jason J Bergsbaken, Elizabeth N Dow |
| المصدر: | Journal of Oncology Pharmacy Practice. 25:954-960 |
| بيانات النشر: | SAGE Publications, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, Immune checkpoint inhibitors, Programmed Cell Death 1 Receptor, Pharmacist, Antineoplastic Agents, Pharmacists, B7-H1 Antigen, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Humans, Medicine, CTLA-4 Antigen, Pharmacology (medical), 030212 general & internal medicine, Aged, Aged, 80 and over, business.industry, Middle Aged, Immune checkpoint, Cancer treatment, Oncology, 030220 oncology & carcinogenesis, Cancer research, Female, Pharmacy Service, Hospital, business |
| الوصف: | Introduction The development of immune checkpoint inhibitors has revolutionized cancer treatment and is now a part of the treatment paradigm for several malignancies. Although immune checkpoint inhibitors are generally well tolerated, treatment is associated with immune-related adverse events, some serious and potentially life threatening. Early identification and prompt appropriate management of immune-related adverse events are crucial to prevent morbidity and mortality. The complexity and severity of immune-related adverse events require interdisciplinary collaboration to optimize care. Patient and caregiver education and continued communication between patients and members of the oncology care team are vital for timely recognition and successful management of immune-related adverse events. The objective of this program is to provide a proof of concept; a pharmacist-led immune checkpoint inhibitor management program will increase early recognition and management of immune-related adverse events through patient and caregiver education and proactively assessing patients for toxicities. Methods At the University of Wisconsin Carbone Cancer Center, we developed and implemented a pharmacist-driven program, referred to as the immune checkpoint inhibitor program, which aimed to ensure patient and caregiver education and continuous monitoring of immune-related adverse events. This program utilized pharmacist–patient encounters to improve patient and caregiver education and follow-up monitoring. The design and implementation are detailed. Pharmacist interventions and patient outcomes were evaluated. Results At interim analysis, 47 patients were enrolled in the program and pharmacists completed 34 interventions on 26 patients. Pharmacists are well positioned to educate patients and caregivers on immune checkpoint inhibitor therapy and provide proactive monitoring to detect immune-related adverse events. We hypothesize that the interventions made by pharmacist may lead to earlier recognition and treatment of immune-related adverse events. |
| تدمد: | 1477-092X 1078-1552 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2d5bd6b52ae36f21902a93be144774Test https://doi.org/10.1177/1078155218817937Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....3c2d5bd6b52ae36f21902a93be144774 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1477092X 10781552 |
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