Pharmacokinetics of Mycophenolic Acid and Its Glucuronidated Metabolites in Stable Lung Transplant Recipients
| العنوان: | Pharmacokinetics of Mycophenolic Acid and Its Glucuronidated Metabolites in Stable Lung Transplant Recipients |
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| المؤلفون: | Mary H H Ensom, K. Wayne Riggs, Robert D. Levy, Nilufar Partovi, Lillian S L Ting |
| المصدر: | Annals of Pharmacotherapy. 40:1509-1516 |
| بيانات النشر: | SAGE Publications, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Adult, Male, 030213 general clinical medicine, Metabolite, Pharmacology, Mycophenolate, 030226 pharmacology & pharmacy, Mycophenolic acid, 03 medical and health sciences, chemistry.chemical_compound, Glucuronides, 0302 clinical medicine, Pharmacokinetics, medicine, Humans, Pharmacology (medical), Active metabolite, Aged, Kidney, business.industry, Middle Aged, Mycophenolic Acid, Transplantation, medicine.anatomical_structure, chemistry, Female, business, Glucuronide, Lung Transplantation, medicine.drug |
| الوصف: | Background: Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil, an immunosuppressive agent commonly used in solid organ transplantation. MPA is metabolized to the inactive metabolite 7-O-mycophenolic acid glucuronide (MPAG) and the active metabolite acyl glucuronide (AcMPAG). Pharmacokinetic profiling of MPA by determining AUC is a tool for determining drug exposure. Many studies, conducted primarily in kidney and some heart and liver transplant recipients, have shown wide interpatient variability in MPA's pharmacokinetic parameters. There have been few studies in the lung transplant group and, even though the lung is not involved in drug elimination, these patients may have different MPA pharmacokinetic characteristics. Objective: To characterize the pharmacokinetic parameters and metabolic ratios of MPA in stable adult lung transplant recipients. Methods: In an open-label manner, lung transplant recipients were recruited. Blood samples were obtained at 0, 0.3, 0.6, 1, 1.5, 2, 4, 6, 8, 10, and 12 hours postdose. Plasma was separated and acidified for drug concentration analysis (MPA, MPAG, AcMPAG) by an HPLC–ultraviolet detection method. Conventional pharmacokinetic parameters were determined via noncompartmental methods. Results: There was large interpatient variability in all pharmacokinetic parameters of MPA, MPAG, and AcMPAG. Similar variability was observed after stratifying patients into concomitant medication groups: cyclosporine and tacrolimus. There was a trend for the tacrolimus group to have a higher dose-normalized AUC, higher AUC, lower apparent clearance, and lower AUC ratio of AcMPAG/MPA compared with the cyclosporine group. In addition, the cyclosporine group had a lower minimum concentration and higher AUC ratio of MPAG/MPA than did the tacrolimus group (p < 0.05). Conclusions: Because of the large interpatient variability in the pharmacokinetic parameters of MPA, MPAG, and AcMPAG, therapeutic drug monitoring of MPA and its metabolites in lung transplant recipients may be beneficial. |
| تدمد: | 1542-6270 1060-0280 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf336d0880f3c64bc82eb6b830ea83dTest https://doi.org/10.1345/aph.1h149Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....3bf336d0880f3c64bc82eb6b830ea83d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15426270 10600280 |
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