Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes
| العنوان: | Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes |
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| المؤلفون: | Matthias von Herrath, Jose Zapardiel-Gonzalo, Teresa Rodriguez-Calvo, Olov Ekwall, Natalie Amirian |
| المصدر: | Diabetes |
| بيانات النشر: | American Diabetes Association, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, CD4-Positive T-Lymphocytes, Male, Cell type, medicine.medical_specialty, endocrine system, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Fluorescent Antibody Technique, CD11c, 030209 endocrinology & metabolism, CD8-Positive T-Lymphocytes, In Vitro Techniques, Pathophysiology, Pathogenesis, Islets of Langerhans, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, MHC class I, Internal Medicine, medicine, Humans, Endocrine system, Cytotoxic T cell, 030304 developmental biology, 0303 health sciences, Type 1 diabetes, biology, nutritional and metabolic diseases, medicine.disease, Pancreas, Exocrine, 3. Good health, Diabetes Mellitus, Type 1, Endocrinology, Immunology, biology.protein, Female, Erratum, Insulitis |
| الوصف: | Type 1 diabetes (T1D) results from a complex interplay between genetic susceptibility and environmental factors that have been implicated in the pathogenesis of disease both as triggers and potentiators of β-cell destruction. CD8 T cells are the main cell type found in human islets, and they have been shown in vitro to be capable of killing β-cells overexpressing MHC class I. In this study, we report that CD8 T cells infiltrate the exocrine pancreas of diabetic subjects in high numbers and not only endocrine areas. T1D subjects present significantly higher CD8 T cell density in the exocrine tissue without the presence of prominent insulitis. Even T1D donors without remaining insulin-containing islets and long disease duration show elevated levels of CD8 T cells in the exocrine compartment. In addition, higher numbers of CD4+ and CD11c+ cells were found in the exocrine tissue. Preliminary data in type 2 diabetic (T2D) subjects indicate that overall, there might be a spontaneous inflammatory infiltration of the exocrine tissue, common to both T1D and T2D subjects. Our study provides the first information on the precise tissue distribution of CD8 T cells in pancreata from T1D, T2D, autoantibody-positive, and healthy control subjects. |
| اللغة: | English |
| تدمد: | 1939-327X 0012-1797 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b188c5ea040c5cbaca4a2a72d6d09d9Test http://europepmc.org/articles/PMC4207385Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3b188c5ea040c5cbaca4a2a72d6d09d9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1939327X 00121797 |
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