Investigating the Effects of Seizures on Procedural Memory Performance in Patients with Epilepsy
| العنوان: | Investigating the Effects of Seizures on Procedural Memory Performance in Patients with Epilepsy |
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| المؤلفون: | Frank J. van Schalkwijk, Laurie A. Miller, Yvonne Höller, Walter Roland Gruber, Eugen Trinka |
| المصدر: | Brain Sciences Brain Sciences; Volume 11; Issue 2; Pages: 261 Brain Sciences, Vol 11, Iss 261, p 261 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Motor sequence, offline consolidation, business.industry, General Neuroscience, epilepsy, motor learning, Memory retention, Audiology, medicine.disease, Procedural memory, Article, lcsh:RC321-571, Temporal lobe, Epilepsy, Seizure control, Medicine, In patient, Motor learning, business, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry |
| الوصف: | Memory complaints are frequently reported by patients with epilepsy and are associated with seizure occurrence. Yet, the direct effects of seizures on memory retention are difficult to assess given their unpredictability. Furthermore, previous investigations have predominantly assessed declarative memory. This study evaluated within-subject effects of seizure occurrence on retention and consolidation of a procedural motor sequence learning task in patients with epilepsy undergoing continuous monitoring for five consecutive days. Of the total sample of patients considered for analyses (N = 53, Mage = 32.92 ± 13.80 y, range = 18–66 y; 43% male), 15 patients experienced seizures and were used for within-patient analyses. Within-patient contrasts showed general improvements over seizure-free (day + night) and seizure-affected retention periods. Yet, exploratory within-subject contrasts for patients diagnosed with temporal lobe epilepsy (n = 10) showed that only seizure-free retention periods resulted in significant improvements, as no performance changes were observed following seizure-affected retention. These results indicate general performance improvements and offline consolidation of procedural memory during the day and night. Furthermore, these results suggest the relevance of healthy temporal lobe functioning for successful consolidation of procedural information, as well as the importance of seizure control for effective retention and consolidation of procedural memory. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2076-3425 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b142aa8ad9a6f544e6c50b9b1fb3c4bTest http://europepmc.org/articles/PMC7922212Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3b142aa8ad9a6f544e6c50b9b1fb3c4b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20763425 |
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