Association Between Hemostatic Profile and Migraine: A Mendelian Randomization Analysis
| العنوان: | Association Between Hemostatic Profile and Migraine: A Mendelian Randomization Analysis |
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| المؤلفون: | Yanjun Guo, Pamela M. Rist, Paul M. Ridker, Nicholas L. Smith, Daniel I. Chasman, Paul S. de Vries, Tobias Kurth, Maria Sabater-Lleal |
| المصدر: | Neurology NEUROLOGY r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| بيانات النشر: | Lippincott Williams & Wilkins, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Migraine without Aura, medicine.medical_specialty, Migraine Disorders, Migraine with Aura, Fibrinogen, Article, Fibrin Fibrinogen Degradation Products, 03 medical and health sciences, 0302 clinical medicine, Von Willebrand factor, Internal medicine, hemic and lymphatic diseases, Mendelian randomization, Plasminogen Activator Inhibitor 1, von Willebrand Factor, medicine, Humans, Genetic Predisposition to Disease, International Normalized Ratio, Factor XI, Fibrinopeptide A, Hemostasis, Factor VIII, biology, business.industry, Mendelian Randomization Analysis, Odds ratio, Factor VII, medicine.disease, Migraine with aura, 030104 developmental biology, Endocrinology, Migraine, Case-Control Studies, Tissue Plasminogen Activator, biology.protein, Prothrombin Time, Partial Thromboplastin Time, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery, medicine.drug, Genome-Wide Association Study |
| الوصف: | ObjectiveTo assess support for a causal relationship between hemostatic measures and migraine susceptibility using genetic instrumental analysis.MethodsTwo-sample Mendelian randomization instrumental analyses leveraging available genome-wide association study (GWAS) summary statistics were applied to hemostatic measures as potentially causal for migraine and its subtypes, migraine with aura (MA) and migraine without aura (MO). Twelve blood-based measures of hemostasis were examined, including plasma level or activity of 8 hemostatic factors and 2 fibrinopeptides together with 2 hemostasis clinical tests.ResultsThere were significant instrumental effects between increased coagulation factor VIII activity (FVIII; odds ratio [95% confidence interval] 1.05 [1.03, 1.08]/SD, p = 6.08 × 10−05), von Willebrand factor level (vWF; 1.05 [1.03, 1.08]/SD, p = 2.25 × 10−06), and phosphorylated fibrinopeptide A level (1.13 [1.07, 1.19]/SD, p = 5.44 × 10−06) with migraine susceptibility. When extended to migraine subtypes, FVIII, vWF, and phosphorylated fibrinopeptide A showed slightly stronger effects with MA than overall migraine. Fibrinogen level was inversely linked with MA (0.76 [0.64, 0.91]/SD, p = 2.32 × 10−03) but not overall migraine. None of the hemostatic factors was linked with MO. In sensitivity analysis, effects for fibrinogen and phosphorylated fibrinopeptide A were robust, whereas independent effects of FVIII and vWF could not be distinguished, and FVIII associations were potentially affected by pleiotropy at the ABO locus. Causal effects from migraine to the hemostatic measures were not supported in reverse Mendelian randomization. However, MA was not included due to lack of instruments.ConclusionsThe findings support potential causality of increased FVIII, vWF, and phosphorylated fibrinopeptide A and decreased fibrinogen in migraine susceptibility, especially for MA, potentially revealing etiologic relationships between hemostasis and migraine. |
| اللغة: | English |
| تدمد: | 0028-3878 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a94b1e401e791cab2f2ef7664265a89Test https://europepmc.org/articles/PMC8205479Test/ |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3a94b1e401e791cab2f2ef7664265a89 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00283878 |
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