Musculoskeletal Complications in Type 1 Diabetes
| العنوان: | Musculoskeletal Complications in Type 1 Diabetes |
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| المؤلفون: | Carol Mahony, Patricia A. Cleary, Annette Barnie, Barbara H. Braffett, David M. Nathan, Patricia Gatcomb, J. Harth, Janie Lipps, Ellen Golden, Mary E. Larkin, Lisa Diminick, Gayle M. Lorenzi |
| المصدر: | Diabetes Care |
| بيانات النشر: | American Diabetes Association, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, Time Factors, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Physical examination, Disability Evaluation, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Surveys and Questionnaires, Internal medicine, Diabetes mellitus, Dash, Prevalence, Internal Medicine, medicine, Humans, Medical history, Musculoskeletal Diseases, 030212 general & internal medicine, Epidemiology/Health Services Research, Carpal tunnel syndrome, Advanced and Specialized Nursing, Type 1 diabetes, medicine.diagnostic_test, business.industry, Middle Aged, medicine.disease, 3. Good health, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Capsulitis, Cohort, Physical therapy, Female, Joint Diseases, business, Diabetic Angiopathies, Follow-Up Studies |
| الوصف: | OBJECTIVE The development of periarticular thickening of skin on the hands and limited joint mobility (cheiroarthropathy) is associated with diabetes and can lead to significant disability. The objective of this study was to describe the prevalence of cheiroarthropathy in the well-characterized Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) cohort and examine associated risk factors, microvascular complications, and the effect of former DCCT therapy (intensive [INT] vs. conventional [CONV]) on its development. RESEARCH DESIGN AND METHODS This cross-sectional analysis was performed in 1,217 participants (95% of the active cohort) in EDIC years 18/19 after an average of 24 years of follow-up. Cheiroarthropathy—defined as the presence of any one of the following: adhesive capsulitis, carpal tunnel syndrome, flexor tenosynovitis, Dupuytren's contracture, or a positive prayer sign—was assessed using a targeted medical history and standardized physical examination. A self-administered questionnaire (Disabilities of the Arm, Shoulder and Hand [DASH]) assessed functional disability. RESULTS Cheiroarthropathy was present in 66% of subjects (64% of the INT group and 68% of the CONV group; P = 0.1640) and was associated with age, sex, diabetes duration, skin intrinsic fluorescence, HbA1c, neuropathy, and retinopathy (P < 0.005 for each). DASH functional disability scores were worse among subjects with cheiroarthropathy (P < 0.0001). CONCLUSIONS Cheiroarthropathy is common in people with type 1 diabetes of long duration (∼30 years) and is related to longer duration and higher levels of glycemia. Clinicians should include cheiroarthropathy in their routine history and physical examination of patients with type 1 diabetes because it causes clinically significant functional disability. |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a85df17a76194b4d7c46f41041162b9Test https://doi.org/10.2337/dc13-2361Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3a85df17a76194b4d7c46f41041162b9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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